Interferon-λs and Plasmacytoid Dendritic Cells: A Close Relationship
Interferon lambdas (IFNλs) are recently discovered cytokines acting not only at the first line of defense against viral infections but also at the mucosal barriers. In fact, a peculiar feature of the IFNλ system is the restricted expression of the functional IFNλR, which is known to be limited to ep...
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doaj-c358ad3373af41d98906534d5b72ce3d2020-11-24T21:27:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-08-01810.3389/fimmu.2017.01015291888Interferon-λs and Plasmacytoid Dendritic Cells: A Close RelationshipGiulia Finotti0Nicola Tamassia1Marco A. Cassatella2Department of Medicine, Section of General Pathology, University of Verona, Verona, ItalyDepartment of Medicine, Section of General Pathology, University of Verona, Verona, ItalyDepartment of Medicine, Section of General Pathology, University of Verona, Verona, ItalyInterferon lambdas (IFNλs) are recently discovered cytokines acting not only at the first line of defense against viral infections but also at the mucosal barriers. In fact, a peculiar feature of the IFNλ system is the restricted expression of the functional IFNλR, which is known to be limited to epithelial cells and discrete leukocyte subsets, including the plasmacytoid dendritic cells (pDCs). In the latter case, current data, discussed in this minireview, indicate that IFNλs positively regulate various pDC functions, including pDC expression of interferon-dependent gene (ISG) mRNAs, production of cytokines, survival, and phenotype. Although the knowledge of the effects on pDCs by IFNλs is still incomplete, we speculate that the peculiar pDC responsiveness to IFNλs provide unique advantages for these innate immune cells, not only for viral infections but also during autoimmune disorders and/or tumors, in which pDC involvement and activation variably contribute to their pathogenesis.http://journal.frontiersin.org/article/10.3389/fimmu.2017.01015/fullplasmacytoid dendritic cellsinterferon lambdainnate immunityIFNαIL-3CXCL10 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giulia Finotti Nicola Tamassia Marco A. Cassatella |
spellingShingle |
Giulia Finotti Nicola Tamassia Marco A. Cassatella Interferon-λs and Plasmacytoid Dendritic Cells: A Close Relationship Frontiers in Immunology plasmacytoid dendritic cells interferon lambda innate immunity IFNα IL-3 CXCL10 |
author_facet |
Giulia Finotti Nicola Tamassia Marco A. Cassatella |
author_sort |
Giulia Finotti |
title |
Interferon-λs and Plasmacytoid Dendritic Cells: A Close Relationship |
title_short |
Interferon-λs and Plasmacytoid Dendritic Cells: A Close Relationship |
title_full |
Interferon-λs and Plasmacytoid Dendritic Cells: A Close Relationship |
title_fullStr |
Interferon-λs and Plasmacytoid Dendritic Cells: A Close Relationship |
title_full_unstemmed |
Interferon-λs and Plasmacytoid Dendritic Cells: A Close Relationship |
title_sort |
interferon-λs and plasmacytoid dendritic cells: a close relationship |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2017-08-01 |
description |
Interferon lambdas (IFNλs) are recently discovered cytokines acting not only at the first line of defense against viral infections but also at the mucosal barriers. In fact, a peculiar feature of the IFNλ system is the restricted expression of the functional IFNλR, which is known to be limited to epithelial cells and discrete leukocyte subsets, including the plasmacytoid dendritic cells (pDCs). In the latter case, current data, discussed in this minireview, indicate that IFNλs positively regulate various pDC functions, including pDC expression of interferon-dependent gene (ISG) mRNAs, production of cytokines, survival, and phenotype. Although the knowledge of the effects on pDCs by IFNλs is still incomplete, we speculate that the peculiar pDC responsiveness to IFNλs provide unique advantages for these innate immune cells, not only for viral infections but also during autoimmune disorders and/or tumors, in which pDC involvement and activation variably contribute to their pathogenesis. |
topic |
plasmacytoid dendritic cells interferon lambda innate immunity IFNα IL-3 CXCL10 |
url |
http://journal.frontiersin.org/article/10.3389/fimmu.2017.01015/full |
work_keys_str_mv |
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