Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease

The left and right ventricles of the four-chambered heart have distinct developmental origins and functions. Chamber-specific developmental programming underlies the differential gene expression of ion channel subunits regulating cardiac electrophysiology that persists into adulthood. Here, we discu...

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Main Authors:	Catherine E. Lipovsky, Brittany D. Brumback, Aditi Khandekar, Stacey L. Rentschler
Format:	Article
Language:	English
Published:	MDPI AG 2018-03-01
Series:	Journal of Cardiovascular Development and Disease
Subjects:	cardiac development electrophysiology optical mapping ECGI
Online Access:	http://www.mdpi.com/2308-3425/5/1/16

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spelling	doaj-c35f6079ed6942949a1c904d4760f6a12020-11-24T23:53:27ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252018-03-01511610.3390/jcdd5010016jcdd5010016Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and DiseaseCatherine E. Lipovsky0Brittany D. Brumback1Aditi Khandekar2Stacey L. Rentschler3Department of Medicine, Cardiovascular Division, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Ave, St. Louis, MO 63110, USADepartment of Medicine, Cardiovascular Division, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Ave, St. Louis, MO 63110, USADepartment of Medicine, Cardiovascular Division, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Ave, St. Louis, MO 63110, USADepartment of Medicine, Cardiovascular Division, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Ave, St. Louis, MO 63110, USAThe left and right ventricles of the four-chambered heart have distinct developmental origins and functions. Chamber-specific developmental programming underlies the differential gene expression of ion channel subunits regulating cardiac electrophysiology that persists into adulthood. Here, we discuss regional specific electrical responses to genetic mutations and cardiac stressors, their clinical correlations, and describe many of the multi-scale techniques commonly used to analyze electrophysiological regional heterogeneity.http://www.mdpi.com/2308-3425/5/1/16cardiac developmentelectrophysiologyoptical mappingECGI
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Catherine E. Lipovsky Brittany D. Brumback Aditi Khandekar Stacey L. Rentschler
spellingShingle	Catherine E. Lipovsky Brittany D. Brumback Aditi Khandekar Stacey L. Rentschler Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease Journal of Cardiovascular Development and Disease cardiac development electrophysiology optical mapping ECGI
author_facet	Catherine E. Lipovsky Brittany D. Brumback Aditi Khandekar Stacey L. Rentschler
author_sort	Catherine E. Lipovsky
title	Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease
title_short	Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease
title_full	Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease
title_fullStr	Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease
title_full_unstemmed	Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease
title_sort	multi-scale assessments of cardiac electrophysiology reveal regional heterogeneity in health and disease
publisher	MDPI AG
series	Journal of Cardiovascular Development and Disease
issn	2308-3425
publishDate	2018-03-01
description	The left and right ventricles of the four-chambered heart have distinct developmental origins and functions. Chamber-specific developmental programming underlies the differential gene expression of ion channel subunits regulating cardiac electrophysiology that persists into adulthood. Here, we discuss regional specific electrical responses to genetic mutations and cardiac stressors, their clinical correlations, and describe many of the multi-scale techniques commonly used to analyze electrophysiological regional heterogeneity.
topic	cardiac development electrophysiology optical mapping ECGI
url	http://www.mdpi.com/2308-3425/5/1/16
work_keys_str_mv	AT catherineelipovsky multiscaleassessmentsofcardiacelectrophysiologyrevealregionalheterogeneityinhealthanddisease AT brittanydbrumback multiscaleassessmentsofcardiacelectrophysiologyrevealregionalheterogeneityinhealthanddisease AT aditikhandekar multiscaleassessmentsofcardiacelectrophysiologyrevealregionalheterogeneityinhealthanddisease AT staceylrentschler multiscaleassessmentsofcardiacelectrophysiologyrevealregionalheterogeneityinhealthanddisease
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Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease

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