The impact of urate-lowering therapy on kidney function (IMPULsKF)
The concept of trial launched in Ukraine in 2017 with POEM design and 36-months duration is presented. It aims to investigate the impact of two target levels of urate-lowering therapy caused by hyperuricemia on kidney function and chronic kidney disease (CKD) progression measured by estimated glomer...
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
Publishing House Zaslavsky
2017-04-01
|
Series: | Počki |
Subjects: | |
Online Access: | http://kidneys.zaslavsky.com.ua/article/view/102786 |
id |
doaj-c361df1fcdf64d6ebdcb1bb4a1250892 |
---|---|
record_format |
Article |
spelling |
doaj-c361df1fcdf64d6ebdcb1bb4a12508922020-11-25T01:05:56ZengPublishing House ZaslavskyPočki 2307-12572307-12652017-04-0162919310.22141/2307-1257.6.2.2017.102786102786The impact of urate-lowering therapy on kidney function (IMPULsKF)D.D. Ivanov0Shupyk National Medical Academy of Postgraduate Education, Kyiv, UkraineThe concept of trial launched in Ukraine in 2017 with POEM design and 36-months duration is presented. It aims to investigate the impact of two target levels of urate-lowering therapy caused by hyperuricemia on kidney function and chronic kidney disease (CKD) progression measured by estimated glomerular filtration rate and albuminuria in 180 patients with gout (n = 90) and with CKD (n = 90). The main current tasks include: 1) evaluation of serum urate acid (SUA) level most potential preserving kidney function; 2) the new onset of gout attacks depending on SUA level, both in gout and CKD objects; 3) safety and side effects of target and ultra-low SUA levels for evidence-based urate-lowering therapy optimal regime in CKD and non-CKD with gout.http://kidneys.zaslavsky.com.ua/article/view/102786urate-lowering therapykidney functionhyperuicemiachronic kidney diseasegout |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
D.D. Ivanov |
spellingShingle |
D.D. Ivanov The impact of urate-lowering therapy on kidney function (IMPULsKF) Počki urate-lowering therapy kidney function hyperuicemia chronic kidney disease gout |
author_facet |
D.D. Ivanov |
author_sort |
D.D. Ivanov |
title |
The impact of urate-lowering therapy on kidney function (IMPULsKF) |
title_short |
The impact of urate-lowering therapy on kidney function (IMPULsKF) |
title_full |
The impact of urate-lowering therapy on kidney function (IMPULsKF) |
title_fullStr |
The impact of urate-lowering therapy on kidney function (IMPULsKF) |
title_full_unstemmed |
The impact of urate-lowering therapy on kidney function (IMPULsKF) |
title_sort |
impact of urate-lowering therapy on kidney function (impulskf) |
publisher |
Publishing House Zaslavsky |
series |
Počki |
issn |
2307-1257 2307-1265 |
publishDate |
2017-04-01 |
description |
The concept of trial launched in Ukraine in 2017 with POEM design and 36-months duration is presented. It aims to investigate the impact of two target levels of urate-lowering therapy caused by hyperuricemia on kidney function and chronic kidney disease (CKD) progression measured by estimated glomerular filtration rate and albuminuria in 180 patients with gout (n = 90) and with CKD (n = 90). The main current tasks include: 1) evaluation of serum urate acid (SUA) level most potential preserving kidney function; 2) the new onset of gout attacks depending on SUA level, both in gout and CKD objects; 3) safety and side effects of target and ultra-low SUA levels for evidence-based urate-lowering therapy optimal regime in CKD and non-CKD with gout. |
topic |
urate-lowering therapy kidney function hyperuicemia chronic kidney disease gout |
url |
http://kidneys.zaslavsky.com.ua/article/view/102786 |
work_keys_str_mv |
AT ddivanov theimpactofurateloweringtherapyonkidneyfunctionimpulskf AT ddivanov impactofurateloweringtherapyonkidneyfunctionimpulskf |
_version_ |
1725192375890870272 |