Phosphatidylglycerol in lung surfactant. III. Possible modifier of surfactant function
Lamellar bodies and alveolar lavage from adult mammalian lung contain unusually high concentrations of phosphatidylglycerol that could serve as a sensitive indicator of surfactant. Phosphatidylglycerol was absent and phosphatidylinositol was correspondingly prominent in surfactant from the preterm r...
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1976-05-01
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doaj-c36511e0d0bf4f0787c4e1d17e5983792021-04-24T05:49:45ZengElsevierJournal of Lipid Research0022-22751976-05-01173257262Phosphatidylglycerol in lung surfactant. III. Possible modifier of surfactant functionM Hallman0L Gluck1Department of Pediatrics, University of California, San Diego, La Jolla, California 92093; Present address: University of Helsinki, Childrens Hospital, 00290 Helsinki 29, FinlandDepartment of Pediatrics, University of California, San Diego, La Jolla, California 92093Lamellar bodies and alveolar lavage from adult mammalian lung contain unusually high concentrations of phosphatidylglycerol that could serve as a sensitive indicator of surfactant. Phosphatidylglycerol was absent and phosphatidylinositol was correspondingly prominent in surfactant from the preterm rabbit fetus. Phosphatidylglycerol rapidly appeared and phosphatidylinositol decreased following the delivery. Surfactant isolated from the prematurely born rabbit or from humans with respiratory distress syndrome never contained phosphatidylglycerol.Comparison between lamellar bodies from fetal and postnatal rabbits revealed remarkably similar composition except for the acidic phospholipids; however, the physico-chemical properties were different. The compressibility of the surface film (i.e. the ratio of the fractional decrease in surface area and the corresponding decrease in surface tension) at low surface tensions was higher with fetal than with postnatal surfactant, whereas the difference in minimum surface tensions was small. These data suggest that phosphatidylglycerol is not an essential component required for the formation of the complex, but it improves the properties of surfactant in stabilizing the alveoli.http://www.sciencedirect.com/science/article/pii/S0022227520369820lamellar inclusion bodydipalmitoyl lecithinlung mechanics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M Hallman L Gluck |
spellingShingle |
M Hallman L Gluck Phosphatidylglycerol in lung surfactant. III. Possible modifier of surfactant function Journal of Lipid Research lamellar inclusion body dipalmitoyl lecithin lung mechanics |
author_facet |
M Hallman L Gluck |
author_sort |
M Hallman |
title |
Phosphatidylglycerol in lung surfactant. III. Possible modifier of surfactant function |
title_short |
Phosphatidylglycerol in lung surfactant. III. Possible modifier of surfactant function |
title_full |
Phosphatidylglycerol in lung surfactant. III. Possible modifier of surfactant function |
title_fullStr |
Phosphatidylglycerol in lung surfactant. III. Possible modifier of surfactant function |
title_full_unstemmed |
Phosphatidylglycerol in lung surfactant. III. Possible modifier of surfactant function |
title_sort |
phosphatidylglycerol in lung surfactant. iii. possible modifier of surfactant function |
publisher |
Elsevier |
series |
Journal of Lipid Research |
issn |
0022-2275 |
publishDate |
1976-05-01 |
description |
Lamellar bodies and alveolar lavage from adult mammalian lung contain unusually high concentrations of phosphatidylglycerol that could serve as a sensitive indicator of surfactant. Phosphatidylglycerol was absent and phosphatidylinositol was correspondingly prominent in surfactant from the preterm rabbit fetus. Phosphatidylglycerol rapidly appeared and phosphatidylinositol decreased following the delivery. Surfactant isolated from the prematurely born rabbit or from humans with respiratory distress syndrome never contained phosphatidylglycerol.Comparison between lamellar bodies from fetal and postnatal rabbits revealed remarkably similar composition except for the acidic phospholipids; however, the physico-chemical properties were different. The compressibility of the surface film (i.e. the ratio of the fractional decrease in surface area and the corresponding decrease in surface tension) at low surface tensions was higher with fetal than with postnatal surfactant, whereas the difference in minimum surface tensions was small. These data suggest that phosphatidylglycerol is not an essential component required for the formation of the complex, but it improves the properties of surfactant in stabilizing the alveoli. |
topic |
lamellar inclusion body dipalmitoyl lecithin lung mechanics |
url |
http://www.sciencedirect.com/science/article/pii/S0022227520369820 |
work_keys_str_mv |
AT mhallman phosphatidylglycerolinlungsurfactantiiipossiblemodifierofsurfactantfunction AT lgluck phosphatidylglycerolinlungsurfactantiiipossiblemodifierofsurfactantfunction |
_version_ |
1721511821122207744 |