Current perspective on the role of the interleukin-23/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis)

• Main Authors: Cauli A, Piga M, Floris A, Mathieu A
• Format: Article
• Language: English
• Published: Dove Medical Press 2015-10-01
• Series: ImmunoTargets and Therapy
• Subjects: TH17; IL-17; IL-23; Psoriasis; Psoriatic Arthritis; Ankylosing Spondylitis
• Online Access: https://www.dovepress.com/current-perspective-on-the-role-of-the-interleukin-23interleukin-17-ax-peer-reviewed-article-ITT
• ISSN: 2253-1556

Alberto Cauli, Matteo Piga, Alberto Floris, Alessandro Mathieu Rheumatology Unit, Department of Medical Sciences, Policlinico of the University of Cagliari, Monserrato, Cagliari, Italy Abstract: TH17 is a lymphocyte subset, which is characterized by its polarization to secrete interleukin (IL)-17. IL-23 is the pivotal mediator responsible for TH17 differentiation and the IL-23/IL-17 axis has been strongly implicated in the pathogenesis of several immune mediated diseases, in particular chronic arthritis and skin psoriasis. This review will summarize the basic immunology and the new monoclonal antibodies, which antagonize this pathway allowing a new therapeutic approach. Keywords: TH17, IL-17, IL-23, psoriasis, psoriatic arthritis, ankylosing spondylitis