LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTY
Activation of destructive adaptive and inherited immunity is the main reason of graft opacification by high-risk keratoplasty. Approximately 46% of recipients from this group are absolute resistant to immunosuppressive therapy with glucocorticoids and cyclosporine A and need tolerization. Discovery...
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2011-06-01
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Series: | Vestnik Transplantologii i Iskusstvennyh Organov |
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Online Access: | https://journal.transpl.ru/vtio/article/view/381 |
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doaj-c36d6ae86bc0480bb99523ca6794a86a2021-07-29T09:08:29ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov Vestnik Transplantologii i Iskusstvennyh Organov1995-11912011-06-011329510210.15825/1995-1191-2011-2-95-102324LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTYKh. D. Tonaeva0N. A. Onishchenko1S. A. Borzenok2The Fedorov Eye Microsurgery Federal State Institution, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowThe Fedorov Eye Microsurgery Federal State Institution, MoscowActivation of destructive adaptive and inherited immunity is the main reason of graft opacification by high-risk keratoplasty. Approximately 46% of recipients from this group are absolute resistant to immunosuppressive therapy with glucocorticoids and cyclosporine A and need tolerization. Discovery of limbal mesenchymal stem cells that resemble phenotype of mesenchymal stem cells of bone marrow reveal the prospects of their use like inductors of local immune tolerance in high-risk keratoplasty. It will help to increase percentage of successful engraftment and shorten the period of medical immunosuppression.https://journal.transpl.ru/vtio/article/view/381keratoplastyimmune tolerancelimbal mesenchymal stem cells. |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
Kh. D. Tonaeva N. A. Onishchenko S. A. Borzenok |
spellingShingle |
Kh. D. Tonaeva N. A. Onishchenko S. A. Borzenok LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTY Vestnik Transplantologii i Iskusstvennyh Organov keratoplasty immune tolerance limbal mesenchymal stem cells. |
author_facet |
Kh. D. Tonaeva N. A. Onishchenko S. A. Borzenok |
author_sort |
Kh. D. Tonaeva |
title |
LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTY |
title_short |
LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTY |
title_full |
LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTY |
title_fullStr |
LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTY |
title_full_unstemmed |
LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTY |
title_sort |
limbal transplantation as a method of local immune tolerance induction in high risk keratoplasty |
publisher |
Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
series |
Vestnik Transplantologii i Iskusstvennyh Organov |
issn |
1995-1191 |
publishDate |
2011-06-01 |
description |
Activation of destructive adaptive and inherited immunity is the main reason of graft opacification by high-risk keratoplasty. Approximately 46% of recipients from this group are absolute resistant to immunosuppressive therapy with glucocorticoids and cyclosporine A and need tolerization. Discovery of limbal mesenchymal stem cells that resemble phenotype of mesenchymal stem cells of bone marrow reveal the prospects of their use like inductors of local immune tolerance in high-risk keratoplasty. It will help to increase percentage of successful engraftment and shorten the period of medical immunosuppression. |
topic |
keratoplasty immune tolerance limbal mesenchymal stem cells. |
url |
https://journal.transpl.ru/vtio/article/view/381 |
work_keys_str_mv |
AT khdtonaeva limbaltransplantationasamethodoflocalimmunetoleranceinductioninhighriskkeratoplasty AT naonishchenko limbaltransplantationasamethodoflocalimmunetoleranceinductioninhighriskkeratoplasty AT saborzenok limbaltransplantationasamethodoflocalimmunetoleranceinductioninhighriskkeratoplasty |
_version_ |
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