LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTY

LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTY

Activation of destructive adaptive and inherited immunity is the main reason of graft opacification by high-risk keratoplasty. Approximately 46% of recipients from this group are absolute resistant to immunosuppressive therapy with glucocorticoids and cyclosporine A and need tolerization. Discovery...

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Main Authors: Kh. D. Tonaeva, N. A. Onishchenko, S. A. Borzenok
Format: Article
Language:Russian
Published: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov 2011-06-01
Series:Vestnik Transplantologii i Iskusstvennyh Organov
Subjects:
keratoplasty
immune tolerance
limbal mesenchymal stem cells.
Online Access:https://journal.transpl.ru/vtio/article/view/381
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spelling doaj-c36d6ae86bc0480bb99523ca6794a86a2021-07-29T09:08:29ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov Vestnik Transplantologii i Iskusstvennyh Organov1995-11912011-06-011329510210.15825/1995-1191-2011-2-95-102324LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTYKh. D. Tonaeva0N. A. Onishchenko1S. A. Borzenok2The Fedorov Eye Microsurgery Federal State Institution, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowThe Fedorov Eye Microsurgery Federal State Institution, MoscowActivation of destructive adaptive and inherited immunity is the main reason of graft opacification by high-risk keratoplasty. Approximately 46% of recipients from this group are absolute resistant to immunosuppressive therapy with glucocorticoids and cyclosporine A and need tolerization. Discovery of limbal mesenchymal stem cells that resemble phenotype of mesenchymal stem cells of bone marrow reveal the prospects of their use like inductors of local immune tolerance in high-risk keratoplasty. It will help to increase percentage of successful engraftment and shorten the period of medical immunosuppression.https://journal.transpl.ru/vtio/article/view/381keratoplastyimmune tolerancelimbal mesenchymal stem cells.
collection DOAJ
language Russian
format Article
sources DOAJ
author Kh. D. Tonaeva
N. A. Onishchenko
S. A. Borzenok
spellingShingle Kh. D. Tonaeva
N. A. Onishchenko
S. A. Borzenok
LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTY
Vestnik Transplantologii i Iskusstvennyh Organov
keratoplasty
immune tolerance
limbal mesenchymal stem cells.
author_facet Kh. D. Tonaeva
N. A. Onishchenko
S. A. Borzenok
author_sort Kh. D. Tonaeva
title LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTY
title_short LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTY
title_full LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTY
title_fullStr LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTY
title_full_unstemmed LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTY
title_sort limbal transplantation as a method of local immune tolerance induction in high risk keratoplasty
publisher Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
series Vestnik Transplantologii i Iskusstvennyh Organov
issn 1995-1191
publishDate 2011-06-01
description Activation of destructive adaptive and inherited immunity is the main reason of graft opacification by high-risk keratoplasty. Approximately 46% of recipients from this group are absolute resistant to immunosuppressive therapy with glucocorticoids and cyclosporine A and need tolerization. Discovery of limbal mesenchymal stem cells that resemble phenotype of mesenchymal stem cells of bone marrow reveal the prospects of their use like inductors of local immune tolerance in high-risk keratoplasty. It will help to increase percentage of successful engraftment and shorten the period of medical immunosuppression.
topic keratoplasty
immune tolerance
limbal mesenchymal stem cells.
url https://journal.transpl.ru/vtio/article/view/381
work_keys_str_mv AT khdtonaeva limbaltransplantationasamethodoflocalimmunetoleranceinductioninhighriskkeratoplasty
AT naonishchenko limbaltransplantationasamethodoflocalimmunetoleranceinductioninhighriskkeratoplasty
AT saborzenok limbaltransplantationasamethodoflocalimmunetoleranceinductioninhighriskkeratoplasty
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