New paradigms in the pathogenesis of Otitis Media in children

New paradigms in the pathogenesis of Otitis Media in children

Acute otitis media (AOM) is a multifactorial disease with a significant socioeconomic impact. The pathogenesis of AOM is attributed to a variety of well-established internal and extrinsic factors. Recent evidence strongly points to bacterial biofilm formation as an important contributor to this dise...

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Bibliographic Details
Main Authors: James Mark Coticchia, Michael eChen, Livjot eSachdeva, Sean eMutchnick
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Pediatrics
Subjects:
Biofilms
Otitis Media
Otitis Media with Effusion
Pathogenesis
acute otitis media
middle ear infection
Online Access:http://journal.frontiersin.org/Journal/10.3389/fped.2013.00052/full
Description
Summary:Acute otitis media (AOM) is a multifactorial disease with a significant socioeconomic impact. The pathogenesis of AOM is attributed to a variety of well-established internal and extrinsic factors. Recent evidence strongly points to bacterial biofilm formation as an important contributor to this disease entity. The nasopharynx is a likely reservoir for infection with subsequent seeding of pathogens to the middle ear via planktonic shedding. Various modalities have been used to directly detect biofilm formation in the middle ear mucosa of children with AOM. Further insights into this disease may lead to new strategies for prevention and treatment.
ISSN:2296-2360

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