New paradigms in the pathogenesis of Otitis Media in children

Acute otitis media (AOM) is a multifactorial disease with a significant socioeconomic impact. The pathogenesis of AOM is attributed to a variety of well-established internal and extrinsic factors. Recent evidence strongly points to bacterial biofilm formation as an important contributor to this dise...

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Main Authors: James Mark Coticchia, Michael eChen, Livjot eSachdeva, Sean eMutchnick
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Pediatrics
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fped.2013.00052/full
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spelling doaj-c3709cb0545242beb57a9c0fe72748fe2020-11-24T23:03:40ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602013-12-01110.3389/fped.2013.0005266011New paradigms in the pathogenesis of Otitis Media in childrenJames Mark Coticchia0Michael eChen1Livjot eSachdeva2Sean eMutchnick3Wayne State University School of MedicineWayne State University School of MedicineWayne State University School of MedicineWayne State UniversityAcute otitis media (AOM) is a multifactorial disease with a significant socioeconomic impact. The pathogenesis of AOM is attributed to a variety of well-established internal and extrinsic factors. Recent evidence strongly points to bacterial biofilm formation as an important contributor to this disease entity. The nasopharynx is a likely reservoir for infection with subsequent seeding of pathogens to the middle ear via planktonic shedding. Various modalities have been used to directly detect biofilm formation in the middle ear mucosa of children with AOM. Further insights into this disease may lead to new strategies for prevention and treatment.http://journal.frontiersin.org/Journal/10.3389/fped.2013.00052/fullBiofilmsOtitis MediaOtitis Media with EffusionPathogenesisacute otitis mediamiddle ear infection
collection DOAJ
language English
format Article
sources DOAJ
author James Mark Coticchia
Michael eChen
Livjot eSachdeva
Sean eMutchnick
spellingShingle James Mark Coticchia
Michael eChen
Livjot eSachdeva
Sean eMutchnick
New paradigms in the pathogenesis of Otitis Media in children
Frontiers in Pediatrics
Biofilms
Otitis Media
Otitis Media with Effusion
Pathogenesis
acute otitis media
middle ear infection
author_facet James Mark Coticchia
Michael eChen
Livjot eSachdeva
Sean eMutchnick
author_sort James Mark Coticchia
title New paradigms in the pathogenesis of Otitis Media in children
title_short New paradigms in the pathogenesis of Otitis Media in children
title_full New paradigms in the pathogenesis of Otitis Media in children
title_fullStr New paradigms in the pathogenesis of Otitis Media in children
title_full_unstemmed New paradigms in the pathogenesis of Otitis Media in children
title_sort new paradigms in the pathogenesis of otitis media in children
publisher Frontiers Media S.A.
series Frontiers in Pediatrics
issn 2296-2360
publishDate 2013-12-01
description Acute otitis media (AOM) is a multifactorial disease with a significant socioeconomic impact. The pathogenesis of AOM is attributed to a variety of well-established internal and extrinsic factors. Recent evidence strongly points to bacterial biofilm formation as an important contributor to this disease entity. The nasopharynx is a likely reservoir for infection with subsequent seeding of pathogens to the middle ear via planktonic shedding. Various modalities have been used to directly detect biofilm formation in the middle ear mucosa of children with AOM. Further insights into this disease may lead to new strategies for prevention and treatment.
topic Biofilms
Otitis Media
Otitis Media with Effusion
Pathogenesis
acute otitis media
middle ear infection
url http://journal.frontiersin.org/Journal/10.3389/fped.2013.00052/full
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