New paradigms in the pathogenesis of Otitis Media in children
Acute otitis media (AOM) is a multifactorial disease with a significant socioeconomic impact. The pathogenesis of AOM is attributed to a variety of well-established internal and extrinsic factors. Recent evidence strongly points to bacterial biofilm formation as an important contributor to this dise...
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Frontiers Media S.A.
2013-12-01
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doaj-c3709cb0545242beb57a9c0fe72748fe2020-11-24T23:03:40ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602013-12-01110.3389/fped.2013.0005266011New paradigms in the pathogenesis of Otitis Media in childrenJames Mark Coticchia0Michael eChen1Livjot eSachdeva2Sean eMutchnick3Wayne State University School of MedicineWayne State University School of MedicineWayne State University School of MedicineWayne State UniversityAcute otitis media (AOM) is a multifactorial disease with a significant socioeconomic impact. The pathogenesis of AOM is attributed to a variety of well-established internal and extrinsic factors. Recent evidence strongly points to bacterial biofilm formation as an important contributor to this disease entity. The nasopharynx is a likely reservoir for infection with subsequent seeding of pathogens to the middle ear via planktonic shedding. Various modalities have been used to directly detect biofilm formation in the middle ear mucosa of children with AOM. Further insights into this disease may lead to new strategies for prevention and treatment.http://journal.frontiersin.org/Journal/10.3389/fped.2013.00052/fullBiofilmsOtitis MediaOtitis Media with EffusionPathogenesisacute otitis mediamiddle ear infection |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
James Mark Coticchia Michael eChen Livjot eSachdeva Sean eMutchnick |
spellingShingle |
James Mark Coticchia Michael eChen Livjot eSachdeva Sean eMutchnick New paradigms in the pathogenesis of Otitis Media in children Frontiers in Pediatrics Biofilms Otitis Media Otitis Media with Effusion Pathogenesis acute otitis media middle ear infection |
author_facet |
James Mark Coticchia Michael eChen Livjot eSachdeva Sean eMutchnick |
author_sort |
James Mark Coticchia |
title |
New paradigms in the pathogenesis of Otitis Media in children |
title_short |
New paradigms in the pathogenesis of Otitis Media in children |
title_full |
New paradigms in the pathogenesis of Otitis Media in children |
title_fullStr |
New paradigms in the pathogenesis of Otitis Media in children |
title_full_unstemmed |
New paradigms in the pathogenesis of Otitis Media in children |
title_sort |
new paradigms in the pathogenesis of otitis media in children |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pediatrics |
issn |
2296-2360 |
publishDate |
2013-12-01 |
description |
Acute otitis media (AOM) is a multifactorial disease with a significant socioeconomic impact. The pathogenesis of AOM is attributed to a variety of well-established internal and extrinsic factors. Recent evidence strongly points to bacterial biofilm formation as an important contributor to this disease entity. The nasopharynx is a likely reservoir for infection with subsequent seeding of pathogens to the middle ear via planktonic shedding. Various modalities have been used to directly detect biofilm formation in the middle ear mucosa of children with AOM. Further insights into this disease may lead to new strategies for prevention and treatment. |
topic |
Biofilms Otitis Media Otitis Media with Effusion Pathogenesis acute otitis media middle ear infection |
url |
http://journal.frontiersin.org/Journal/10.3389/fped.2013.00052/full |
work_keys_str_mv |
AT jamesmarkcoticchia newparadigmsinthepathogenesisofotitismediainchildren AT michaelechen newparadigmsinthepathogenesisofotitismediainchildren AT livjotesachdeva newparadigmsinthepathogenesisofotitismediainchildren AT seanemutchnick newparadigmsinthepathogenesisofotitismediainchildren |
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