Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes
Perturbed T cell responses and disturbed cytokine secretion have been shown during SARS-CoV2 infection in patients. Here the authors show reduced polyclonal T cell activity in COVID-19 patients that is caused by plasma factors and linked to poor prognosis and viral persistence.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23334-2 |
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doaj-c371d2526a5d4d4fbe8ed4cc2103dcb32021-05-23T11:12:52ZengNature Publishing GroupNature Communications2041-17232021-05-0112111110.1038/s41467-021-23334-2Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomesKerstin Renner0Tobias Schwittay1Sophia Chaabane2Johanna Gottschling3Christine Müller4Charlotte Tiefenböck5Jan-Niklas Salewski6Frederike Winter7Simone Buchtler8Saidou Balam9Maximilian V. Malfertheiner10Matthias Lubnow11Dirk Lunz12Bernhard Graf13Florian Hitzenbichler14Frank Hanses15Hendrik Poeck16Marina Kreutz17Evelyn Orsó18Ralph Burkhardt19Tanja Niedermair20Christoph Brochhausen21André Gessner22Bernd Salzberger23Matthias Mack24Department of Nephrology, University Hospital RegensburgDepartment of Nephrology, University Hospital RegensburgDepartment of Nephrology, University Hospital RegensburgDepartment of Nephrology, University Hospital RegensburgDepartment of Nephrology, University Hospital RegensburgDepartment of Nephrology, University Hospital RegensburgDepartment of Nephrology, University Hospital RegensburgDepartment of Nephrology, University Hospital RegensburgDepartment of Nephrology, University Hospital RegensburgDepartment of Nephrology, University Hospital RegensburgDepartment of Internal Medicine II, University Hospital RegensburgDepartment of Internal Medicine II, University Hospital RegensburgDepartment of Anesthesiology, University Hospital RegensburgDepartment of Anesthesiology, University Hospital RegensburgDepartment of Infection Prevention and Infectious Diseases, University Hospital RegensburgDepartment of Infection Prevention and Infectious Diseases, University Hospital RegensburgDepartment of Internal Medicine III, University Hospital RegensburgDepartment of Internal Medicine III, University Hospital RegensburgInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital RegensburgInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital RegensburgInstitute of Pathology, University of RegensburgInstitute of Pathology, University of RegensburgInstitute Clinical Microbiology and Hygiene, University Hospital RegensburgDepartment of Infection Prevention and Infectious Diseases, University Hospital RegensburgDepartment of Nephrology, University Hospital RegensburgPerturbed T cell responses and disturbed cytokine secretion have been shown during SARS-CoV2 infection in patients. Here the authors show reduced polyclonal T cell activity in COVID-19 patients that is caused by plasma factors and linked to poor prognosis and viral persistence.https://doi.org/10.1038/s41467-021-23334-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kerstin Renner Tobias Schwittay Sophia Chaabane Johanna Gottschling Christine Müller Charlotte Tiefenböck Jan-Niklas Salewski Frederike Winter Simone Buchtler Saidou Balam Maximilian V. Malfertheiner Matthias Lubnow Dirk Lunz Bernhard Graf Florian Hitzenbichler Frank Hanses Hendrik Poeck Marina Kreutz Evelyn Orsó Ralph Burkhardt Tanja Niedermair Christoph Brochhausen André Gessner Bernd Salzberger Matthias Mack |
| spellingShingle |
Kerstin Renner Tobias Schwittay Sophia Chaabane Johanna Gottschling Christine Müller Charlotte Tiefenböck Jan-Niklas Salewski Frederike Winter Simone Buchtler Saidou Balam Maximilian V. Malfertheiner Matthias Lubnow Dirk Lunz Bernhard Graf Florian Hitzenbichler Frank Hanses Hendrik Poeck Marina Kreutz Evelyn Orsó Ralph Burkhardt Tanja Niedermair Christoph Brochhausen André Gessner Bernd Salzberger Matthias Mack Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes Nature Communications |
| author_facet |
Kerstin Renner Tobias Schwittay Sophia Chaabane Johanna Gottschling Christine Müller Charlotte Tiefenböck Jan-Niklas Salewski Frederike Winter Simone Buchtler Saidou Balam Maximilian V. Malfertheiner Matthias Lubnow Dirk Lunz Bernhard Graf Florian Hitzenbichler Frank Hanses Hendrik Poeck Marina Kreutz Evelyn Orsó Ralph Burkhardt Tanja Niedermair Christoph Brochhausen André Gessner Bernd Salzberger Matthias Mack |
| author_sort |
Kerstin Renner |
| title |
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |
| title_short |
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |
| title_full |
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |
| title_fullStr |
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |
| title_full_unstemmed |
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |
| title_sort |
severe t cell hyporeactivity in ventilated covid-19 patients correlates with prolonged virus persistence and poor outcomes |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-05-01 |
| description |
Perturbed T cell responses and disturbed cytokine secretion have been shown during SARS-CoV2 infection in patients. Here the authors show reduced polyclonal T cell activity in COVID-19 patients that is caused by plasma factors and linked to poor prognosis and viral persistence. |
| url |
https://doi.org/10.1038/s41467-021-23334-2 |
| work_keys_str_mv |
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