Selecting and Using the Appropriate Influenza Vaccine for Each Individual
Despite seasonal influenza vaccines having been routinely used for many decades, influenza A virus continues to pose a global threat to humans, causing high morbidity and mortality each year. The effectiveness of the vaccine is largely dependent on how well matched the vaccine strains are with the c...
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/6/971 |
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doaj-c37ba3e8efdd4544a373ab7f0b0c4c262021-06-01T00:56:34ZengMDPI AGViruses1999-49152021-05-011397197110.3390/v13060971Selecting and Using the Appropriate Influenza Vaccine for Each IndividualToshiki Sekiya0Marumi Ohno1Naoki Nomura2Chimuka Handabile3Masashi Shingai4David C. Jackson5Lorena E. Brown6Hiroshi Kida7International Institute for Zoonosis Control, Hokkaido University, Kita-20 Nishi-10, Kita-ku, Sapporo 001-0020, JapanInternational Institute for Zoonosis Control, Hokkaido University, Kita-20 Nishi-10, Kita-ku, Sapporo 001-0020, JapanInternational Institute for Zoonosis Control, Hokkaido University, Kita-20 Nishi-10, Kita-ku, Sapporo 001-0020, JapanInternational Institute for Zoonosis Control, Hokkaido University, Kita-20 Nishi-10, Kita-ku, Sapporo 001-0020, JapanInternational Institute for Zoonosis Control, Hokkaido University, Kita-20 Nishi-10, Kita-ku, Sapporo 001-0020, JapanInternational Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, JapanInternational Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, JapanInternational Institute for Zoonosis Control, Hokkaido University, Kita-20 Nishi-10, Kita-ku, Sapporo 001-0020, JapanDespite seasonal influenza vaccines having been routinely used for many decades, influenza A virus continues to pose a global threat to humans, causing high morbidity and mortality each year. The effectiveness of the vaccine is largely dependent on how well matched the vaccine strains are with the circulating influenza virus strains. Furthermore, low vaccine efficacy in naïve populations such as young children, or in the elderly, who possess weakened immune systems, indicates that influenza vaccines need to be more personalized to provide broader community protection. Advances in both vaccine technologies and our understanding of influenza virus infection and immunity have led to the design of a variety of alternate vaccine strategies to extend population protection against influenza, some of which are now in use. In this review, we summarize the progress in the field of influenza vaccines, including the advantages and disadvantages of different strategies, and discuss future prospects. We also highlight some of the challenges to be faced in the ongoing effort to control influenza through vaccination.https://www.mdpi.com/1999-4915/13/6/971seasonal influenza vaccinewhole virus particle vaccinepandemic preparednesspriming immune response |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Toshiki Sekiya Marumi Ohno Naoki Nomura Chimuka Handabile Masashi Shingai David C. Jackson Lorena E. Brown Hiroshi Kida |
| spellingShingle |
Toshiki Sekiya Marumi Ohno Naoki Nomura Chimuka Handabile Masashi Shingai David C. Jackson Lorena E. Brown Hiroshi Kida Selecting and Using the Appropriate Influenza Vaccine for Each Individual Viruses seasonal influenza vaccine whole virus particle vaccine pandemic preparedness priming immune response |
| author_facet |
Toshiki Sekiya Marumi Ohno Naoki Nomura Chimuka Handabile Masashi Shingai David C. Jackson Lorena E. Brown Hiroshi Kida |
| author_sort |
Toshiki Sekiya |
| title |
Selecting and Using the Appropriate Influenza Vaccine for Each Individual |
| title_short |
Selecting and Using the Appropriate Influenza Vaccine for Each Individual |
| title_full |
Selecting and Using the Appropriate Influenza Vaccine for Each Individual |
| title_fullStr |
Selecting and Using the Appropriate Influenza Vaccine for Each Individual |
| title_full_unstemmed |
Selecting and Using the Appropriate Influenza Vaccine for Each Individual |
| title_sort |
selecting and using the appropriate influenza vaccine for each individual |
| publisher |
MDPI AG |
| series |
Viruses |
| issn |
1999-4915 |
| publishDate |
2021-05-01 |
| description |
Despite seasonal influenza vaccines having been routinely used for many decades, influenza A virus continues to pose a global threat to humans, causing high morbidity and mortality each year. The effectiveness of the vaccine is largely dependent on how well matched the vaccine strains are with the circulating influenza virus strains. Furthermore, low vaccine efficacy in naïve populations such as young children, or in the elderly, who possess weakened immune systems, indicates that influenza vaccines need to be more personalized to provide broader community protection. Advances in both vaccine technologies and our understanding of influenza virus infection and immunity have led to the design of a variety of alternate vaccine strategies to extend population protection against influenza, some of which are now in use. In this review, we summarize the progress in the field of influenza vaccines, including the advantages and disadvantages of different strategies, and discuss future prospects. We also highlight some of the challenges to be faced in the ongoing effort to control influenza through vaccination. |
| topic |
seasonal influenza vaccine whole virus particle vaccine pandemic preparedness priming immune response |
| url |
https://www.mdpi.com/1999-4915/13/6/971 |
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