A beta-lactam antibiotic dampens excitotoxic inflammatory CNS damage in a mouse model of multiple sclerosis.

A beta-lactam antibiotic dampens excitotoxic inflammatory CNS damage in a mouse model of multiple sclerosis.

In multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), impairment of glial "Excitatory Amino Acid Transporters" (EAATs) together with an excess glutamate-release by invading immune cells causes excitotoxic damage of the central nervous system (CNS)...

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Bibliographic Details
Main Authors: Nico Melzer, Sven G Meuth, Delany Torres-Salazar, Stefan Bittner, Alla L Zozulya, Christian Weidenfeller, Alexandra Kotsiari, Martin Stangel, Christoph Fahlke, Heinz Wiendl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-09-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18773080/pdf/?tool=EBI

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