Evidence of Glycolysis Up-Regulation and Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading of the Failing Human Heart

Evidence of Glycolysis Up-Regulation and Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading of the Failing Human Heart

This study sought to investigate the effects of mechanical unloading on myocardial energetics and the metabolic perturbation of heart failure (HF) in an effort to identify potential new therapeutic targets that could enhance the unloading-induced cardiac recovery. The authors prospectively examined...

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Bibliographic Details
Main Authors: Nikolaos A. Diakos, MD, PhD, Sutip Navankasattusas, PhD, E. Dale Abel, MD, PhD, Jared Rutter, PhD, Lauren McCreath, BS, Peter Ferrin, BS, Stephen H. McKellar, MD, Dylan V. Miller, MD, Song Y. Park, PhD, Russell S. Richardson, PhD, Ralph Deberardinis, MD, James E. Cox, PhD, Abdallah G. Kfoury, MD, Craig H. Selzman, MD, Josef Stehlik, MD, James C. Fang, MD, Dean Y. Li, MD, PhD, Stavros G. Drakos, MD, PhD
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:JACC: Basic to Translational Science
Subjects:
cardiac conditioning
cardiac metabolism
left ventricular assist device
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X16301097

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