Immune Thrombocytopenia causing Abnormal Uterine Bleeding in an Adolescent Girl having Co-Existent Type-1 Neurofibromatosis- Is it an Association or Coincidence?
Immune Thrombocytopenia (ITP) is an autoimmune disorder characterised by a low circulating platelet count. ITP is caused by destruction of antibody-sensitised platelets in the reticuloendothelial system. Majority of the patients with ITP remain asymptomatic or develop only purpura, petechiae or ep...
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doaj-c38a1c6e908c4de3b23bd4cc980875382021-06-01T11:57:05ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2020-11-011411QD01QD0310.7860/JCDR/2020/45876.14180Immune Thrombocytopenia causing Abnormal Uterine Bleeding in an Adolescent Girl having Co-Existent Type-1 Neurofibromatosis- Is it an Association or Coincidence?Charu Sharma0Shavina Bansal1Shashank Shekhar2 Manisha Jhirwal3Payal Patwa4Associate Professor, Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.Senior Resident, Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.Additional Professor, Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.Assistant Professor, Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.Junior Resident, Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.Immune Thrombocytopenia (ITP) is an autoimmune disorder characterised by a low circulating platelet count. ITP is caused by destruction of antibody-sensitised platelets in the reticuloendothelial system. Majority of the patients with ITP remain asymptomatic or develop only purpura, petechiae or epistaxis (83%) but few, very rarely, may present with abnormal uterine bleeding. On the other hand, Neurofibromatosis is an autosomal dominant disorder which can present with either precocious puberty or delayed puberty. This case report highlights a case of a 14-year-old female who presented with heavy menstrual bleeding as a presenting symptom of ITP and was co-incidentally also diagnosed as Neurofibromatosis type 1 (NF-1) during work-up of ITP for multiple hyperpigmented macules (Café-au-lait spots) noticed on her neck, forearm and back and the presence of Lisch nodules in iris. She was managed with steroids, oral contraceptive pills, iron and multivitamin tablets.https://jcdr.net/articles/PDF/14180/45876_CE[Ra1]_F(KM)_PF1(AKA_SL)_PFA(AKA_SL)_PN(SL).pdfcafé-au-lait spotsheavy menstrual bleedinglisch nodulesplatelet countsteroids |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Charu Sharma Shavina Bansal Shashank Shekhar Manisha Jhirwal Payal Patwa |
spellingShingle |
Charu Sharma Shavina Bansal Shashank Shekhar Manisha Jhirwal Payal Patwa Immune Thrombocytopenia causing Abnormal Uterine Bleeding in an Adolescent Girl having Co-Existent Type-1 Neurofibromatosis- Is it an Association or Coincidence? Journal of Clinical and Diagnostic Research café-au-lait spots heavy menstrual bleeding lisch nodules platelet count steroids |
author_facet |
Charu Sharma Shavina Bansal Shashank Shekhar Manisha Jhirwal Payal Patwa |
author_sort |
Charu Sharma |
title |
Immune Thrombocytopenia causing Abnormal Uterine Bleeding in an Adolescent Girl having Co-Existent Type-1 Neurofibromatosis- Is it an Association or Coincidence? |
title_short |
Immune Thrombocytopenia causing Abnormal Uterine Bleeding in an Adolescent Girl having Co-Existent Type-1 Neurofibromatosis- Is it an Association or Coincidence? |
title_full |
Immune Thrombocytopenia causing Abnormal Uterine Bleeding in an Adolescent Girl having Co-Existent Type-1 Neurofibromatosis- Is it an Association or Coincidence? |
title_fullStr |
Immune Thrombocytopenia causing Abnormal Uterine Bleeding in an Adolescent Girl having Co-Existent Type-1 Neurofibromatosis- Is it an Association or Coincidence? |
title_full_unstemmed |
Immune Thrombocytopenia causing Abnormal Uterine Bleeding in an Adolescent Girl having Co-Existent Type-1 Neurofibromatosis- Is it an Association or Coincidence? |
title_sort |
immune thrombocytopenia causing abnormal uterine bleeding in an adolescent girl having co-existent type-1 neurofibromatosis- is it an association or coincidence? |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2020-11-01 |
description |
Immune Thrombocytopenia (ITP) is an autoimmune disorder characterised by a low circulating platelet count. ITP is caused by
destruction of antibody-sensitised platelets in the reticuloendothelial system. Majority of the patients with ITP remain asymptomatic
or develop only purpura, petechiae or epistaxis (83%) but few, very rarely, may present with abnormal uterine bleeding. On the
other hand, Neurofibromatosis is an autosomal dominant disorder which can present with either precocious puberty or delayed
puberty. This case report highlights a case of a 14-year-old female who presented with heavy menstrual bleeding as a presenting
symptom of ITP and was co-incidentally also diagnosed as Neurofibromatosis type 1 (NF-1) during work-up of ITP for multiple
hyperpigmented macules (Café-au-lait spots) noticed on her neck, forearm and back and the presence of Lisch nodules in iris. She
was managed with steroids, oral contraceptive pills, iron and multivitamin tablets. |
topic |
café-au-lait spots heavy menstrual bleeding lisch nodules platelet count steroids |
url |
https://jcdr.net/articles/PDF/14180/45876_CE[Ra1]_F(KM)_PF1(AKA_SL)_PFA(AKA_SL)_PN(SL).pdf |
work_keys_str_mv |
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