TNFSF15 promoter polymorphisms increase the susceptibility to small cell lung cancer: a case-control study
Abstract Background Tumor necrosis factor superfamily member 15 (TNFSF15) is closely related to tumorigenesis and development. This study aimed to investigate the correlations between TNFSF15 polymorphisms and genetic susceptibility to lung cancer. Methods This case-control study included 209 small...
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doaj-c38ec144447d4eb795b5f0d0499515ce2021-04-02T14:46:16ZengBMCBMC Medical Genetics1471-23502019-02-012011710.1186/s12881-019-0762-6TNFSF15 promoter polymorphisms increase the susceptibility to small cell lung cancer: a case-control studyHui Gao0Zeren Niu1Zhi Zhang2Hongjiao Wu3Yuning Xie4Zhenbang Yang5Ang Li6Zhenxian Jia7Xuemei Zhang8College of Life Science, North China University of Science and TechnologyCollege of Life Science, North China University of Science and TechnologyAffliated Tangshan Gongren Hospital, North China University of Science and TechnologyCollege of Life Science, North China University of Science and TechnologyCollege of Life Science, North China University of Science and TechnologySchool of Basic Medical Sciences, North China University of Science and TechnologyCollege of Life Science, North China University of Science and TechnologyCollege of Life Science, North China University of Science and TechnologyCollege of Life Science, North China University of Science and TechnologyAbstract Background Tumor necrosis factor superfamily member 15 (TNFSF15) is closely related to tumorigenesis and development. This study aimed to investigate the correlations between TNFSF15 polymorphisms and genetic susceptibility to lung cancer. Methods This case-control study included 209 small cell lung cancer patients (SCLC), 340 non- small cell lung cancer patients (NSCLC) and 460 health controls. TNFSF15–638 A > G and − 358 T > C polymorphisms were genotyped by polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) analysis. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated by unconditional logistic regression. Results Our results showed that subjects carrying the TNFSF15–638GG genotype or -358CC genotype were more likely to develop SCLC (−638GG, OR = 1.84, 95%CI = 1.13–2.99; -358CC, OR = 2.44, 95%CI = 1.46–4.06), but not NSCLC (P > 0.05). In stratified analysis, −638GG genotype was related to SCLC among males (OR = 1.95, 95%CI = 1.09–3.45, P = 0.023) and older patients (OR = 2.93, 95%CI = 1.44–8.68, P = 0.006). However, -358CC genotype was associated with SCLC among females (OR = 8.42, 95%CI = 2.22–31.89, P = 0.002) and older subjects with OR (95%CI) of 11.04 (3.57–34.15) (P < 0.001). Moreover, TNFSF15 -358CC was linked with a higher risk of SCLC among non-smokers (OR = 2.54, 95%CI = 1.20–5.35, P = 0.015) but not among smokers (OR = 1.88, 95%CI = 0.92–3.84, P = 0.086). Conclusion These findings highlight the importance of TNFSF15 polymorphisms in the development of SCLC.http://link.springer.com/article/10.1186/s12881-019-0762-6TNFSF15Lung cancerSingle nucleotide polymorphismCancer susceptibility |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hui Gao Zeren Niu Zhi Zhang Hongjiao Wu Yuning Xie Zhenbang Yang Ang Li Zhenxian Jia Xuemei Zhang |
spellingShingle |
Hui Gao Zeren Niu Zhi Zhang Hongjiao Wu Yuning Xie Zhenbang Yang Ang Li Zhenxian Jia Xuemei Zhang TNFSF15 promoter polymorphisms increase the susceptibility to small cell lung cancer: a case-control study BMC Medical Genetics TNFSF15 Lung cancer Single nucleotide polymorphism Cancer susceptibility |
author_facet |
Hui Gao Zeren Niu Zhi Zhang Hongjiao Wu Yuning Xie Zhenbang Yang Ang Li Zhenxian Jia Xuemei Zhang |
author_sort |
Hui Gao |
title |
TNFSF15 promoter polymorphisms increase the susceptibility to small cell lung cancer: a case-control study |
title_short |
TNFSF15 promoter polymorphisms increase the susceptibility to small cell lung cancer: a case-control study |
title_full |
TNFSF15 promoter polymorphisms increase the susceptibility to small cell lung cancer: a case-control study |
title_fullStr |
TNFSF15 promoter polymorphisms increase the susceptibility to small cell lung cancer: a case-control study |
title_full_unstemmed |
TNFSF15 promoter polymorphisms increase the susceptibility to small cell lung cancer: a case-control study |
title_sort |
tnfsf15 promoter polymorphisms increase the susceptibility to small cell lung cancer: a case-control study |
publisher |
BMC |
series |
BMC Medical Genetics |
issn |
1471-2350 |
publishDate |
2019-02-01 |
description |
Abstract Background Tumor necrosis factor superfamily member 15 (TNFSF15) is closely related to tumorigenesis and development. This study aimed to investigate the correlations between TNFSF15 polymorphisms and genetic susceptibility to lung cancer. Methods This case-control study included 209 small cell lung cancer patients (SCLC), 340 non- small cell lung cancer patients (NSCLC) and 460 health controls. TNFSF15–638 A > G and − 358 T > C polymorphisms were genotyped by polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) analysis. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated by unconditional logistic regression. Results Our results showed that subjects carrying the TNFSF15–638GG genotype or -358CC genotype were more likely to develop SCLC (−638GG, OR = 1.84, 95%CI = 1.13–2.99; -358CC, OR = 2.44, 95%CI = 1.46–4.06), but not NSCLC (P > 0.05). In stratified analysis, −638GG genotype was related to SCLC among males (OR = 1.95, 95%CI = 1.09–3.45, P = 0.023) and older patients (OR = 2.93, 95%CI = 1.44–8.68, P = 0.006). However, -358CC genotype was associated with SCLC among females (OR = 8.42, 95%CI = 2.22–31.89, P = 0.002) and older subjects with OR (95%CI) of 11.04 (3.57–34.15) (P < 0.001). Moreover, TNFSF15 -358CC was linked with a higher risk of SCLC among non-smokers (OR = 2.54, 95%CI = 1.20–5.35, P = 0.015) but not among smokers (OR = 1.88, 95%CI = 0.92–3.84, P = 0.086). Conclusion These findings highlight the importance of TNFSF15 polymorphisms in the development of SCLC. |
topic |
TNFSF15 Lung cancer Single nucleotide polymorphism Cancer susceptibility |
url |
http://link.springer.com/article/10.1186/s12881-019-0762-6 |
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