Evidence of Experimental Bias in the Life Sciences: Why We Need Blind Data Recording.
Observer bias and other "experimenter effects" occur when researchers' expectations influence study outcome. These biases are strongest when researchers expect a particular result, are measuring subjective variables, and have an incentive to produce data that confirm predictions. To m...
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2015-07-01
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doaj-c39a7796663c435a8cd8c948a67ae1882021-07-02T05:09:03ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852015-07-01137e100219010.1371/journal.pbio.1002190Evidence of Experimental Bias in the Life Sciences: Why We Need Blind Data Recording.Luke HolmanMegan L HeadRobert LanfearMichael D JennionsObserver bias and other "experimenter effects" occur when researchers' expectations influence study outcome. These biases are strongest when researchers expect a particular result, are measuring subjective variables, and have an incentive to produce data that confirm predictions. To minimize bias, it is good practice to work "blind," meaning that experimenters are unaware of the identity or treatment group of their subjects while conducting research. Here, using text mining and a literature review, we find evidence that blind protocols are uncommon in the life sciences and that nonblind studies tend to report higher effect sizes and more significant p-values. We discuss methods to minimize bias and urge researchers, editors, and peer reviewers to keep blind protocols in mind.http://europepmc.org/articles/PMC4496034?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luke Holman Megan L Head Robert Lanfear Michael D Jennions |
spellingShingle |
Luke Holman Megan L Head Robert Lanfear Michael D Jennions Evidence of Experimental Bias in the Life Sciences: Why We Need Blind Data Recording. PLoS Biology |
author_facet |
Luke Holman Megan L Head Robert Lanfear Michael D Jennions |
author_sort |
Luke Holman |
title |
Evidence of Experimental Bias in the Life Sciences: Why We Need Blind Data Recording. |
title_short |
Evidence of Experimental Bias in the Life Sciences: Why We Need Blind Data Recording. |
title_full |
Evidence of Experimental Bias in the Life Sciences: Why We Need Blind Data Recording. |
title_fullStr |
Evidence of Experimental Bias in the Life Sciences: Why We Need Blind Data Recording. |
title_full_unstemmed |
Evidence of Experimental Bias in the Life Sciences: Why We Need Blind Data Recording. |
title_sort |
evidence of experimental bias in the life sciences: why we need blind data recording. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Biology |
issn |
1544-9173 1545-7885 |
publishDate |
2015-07-01 |
description |
Observer bias and other "experimenter effects" occur when researchers' expectations influence study outcome. These biases are strongest when researchers expect a particular result, are measuring subjective variables, and have an incentive to produce data that confirm predictions. To minimize bias, it is good practice to work "blind," meaning that experimenters are unaware of the identity or treatment group of their subjects while conducting research. Here, using text mining and a literature review, we find evidence that blind protocols are uncommon in the life sciences and that nonblind studies tend to report higher effect sizes and more significant p-values. We discuss methods to minimize bias and urge researchers, editors, and peer reviewers to keep blind protocols in mind. |
url |
http://europepmc.org/articles/PMC4496034?pdf=render |
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