Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects
Abstract Background To investigate the effects of coadministration of esaxerenone with amlodipine on the pharmacokinetics (PK) of each drug, and of esaxerenone on the PK of digoxin. Methods In three open-label, single-sequence, crossover studies, healthy Japanese males received single oral doses of...
Main Authors: | Yoshiaki Kirigaya, Masanari Shiramoto, Tomoko Ishizuka, Hinako Uchimaru, Shin Irie, Manabu Kato, Takako Shimizu, Takafumi Nakatsu, Yasuhiro Nishikawa, Hitoshi Ishizuka |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-07-01
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Series: | BMC Pharmacology and Toxicology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40360-020-00423-4 |
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