Comparing model‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patients
Abstract Objective To compare the novel model‐based hemodynamic physiomarker of Dynamic Vasomotor Reactivity (DVR) with biomarkers based on Diffusion Tensor Imaging (DTI) and some widely used neurocognitive scores in terms of their ability to delineate patients with amnestic Mild Cognitive Impairmen...
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doaj-c3a1428e63a645d29b0ea1bde5012d262020-11-25T03:14:51ZengWileyBrain and Behavior2162-32792019-08-0198n/an/a10.1002/brb3.1356Comparing model‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patientsVasilis Z. Marmarelis0Dae C. Shin1Takashi Tarumi2Rong Zhang3Department of Biomedical Engineering University of Southern California Los Angeles CaliforniaBiomedical Simulations Resource Center University of Southern California Los Angeles CaliforniaNeurology and Neurotherapeutics UT Southwestern Medical Center Dallas TexasNeurology and Neurotherapeutics UT Southwestern Medical Center Dallas TexasAbstract Objective To compare the novel model‐based hemodynamic physiomarker of Dynamic Vasomotor Reactivity (DVR) with biomarkers based on Diffusion Tensor Imaging (DTI) and some widely used neurocognitive scores in terms of their ability to delineate patients with amnestic Mild Cognitive Impairment (MCI) from age‐matched cognitively normal controls. Materials & Methods The model‐based DVR and MRI‐based DTI markers were obtained from 36 patients with amnestic MCI and 16 age‐matched controls without cognitive impairment, for whom widely used neurocognitive scores were available. These markers and scores were subsequently compared in terms of statistical delineation between patients and controls. Results It was found that statistically significant delineation between MCI patients and controls was comparable for DVR or DTI markers (p < 0.01). The performance of both types of markers was consistent with the scores of some (but not all) widely used neurocognitive tests. Conclusion Since DTI offers a measure of cerebral white matter integrity, the results suggest that the model‐based hemodynamic marker of DVR may correlate with cognitive impairment due to white matter lesions. This finding is consistent with the hypothesis that dysregulation of cerebral microcirculation may be an early cause of cognitive impairment, which has been recently corroborated by several studies.https://doi.org/10.1002/brb3.1356Alzheimer's diseasecerebral flow regulationdiffusion tensor imaginghemodynamic physiomarkersmild cognitive impairmentmodel‐based diagnostic physiomarkers |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vasilis Z. Marmarelis Dae C. Shin Takashi Tarumi Rong Zhang |
spellingShingle |
Vasilis Z. Marmarelis Dae C. Shin Takashi Tarumi Rong Zhang Comparing model‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patients Brain and Behavior Alzheimer's disease cerebral flow regulation diffusion tensor imaging hemodynamic physiomarkers mild cognitive impairment model‐based diagnostic physiomarkers |
author_facet |
Vasilis Z. Marmarelis Dae C. Shin Takashi Tarumi Rong Zhang |
author_sort |
Vasilis Z. Marmarelis |
title |
Comparing model‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patients |
title_short |
Comparing model‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patients |
title_full |
Comparing model‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patients |
title_fullStr |
Comparing model‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patients |
title_full_unstemmed |
Comparing model‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patients |
title_sort |
comparing model‐based cerebrovascular physiomarkers with dti biomarkers in mci patients |
publisher |
Wiley |
series |
Brain and Behavior |
issn |
2162-3279 |
publishDate |
2019-08-01 |
description |
Abstract Objective To compare the novel model‐based hemodynamic physiomarker of Dynamic Vasomotor Reactivity (DVR) with biomarkers based on Diffusion Tensor Imaging (DTI) and some widely used neurocognitive scores in terms of their ability to delineate patients with amnestic Mild Cognitive Impairment (MCI) from age‐matched cognitively normal controls. Materials & Methods The model‐based DVR and MRI‐based DTI markers were obtained from 36 patients with amnestic MCI and 16 age‐matched controls without cognitive impairment, for whom widely used neurocognitive scores were available. These markers and scores were subsequently compared in terms of statistical delineation between patients and controls. Results It was found that statistically significant delineation between MCI patients and controls was comparable for DVR or DTI markers (p < 0.01). The performance of both types of markers was consistent with the scores of some (but not all) widely used neurocognitive tests. Conclusion Since DTI offers a measure of cerebral white matter integrity, the results suggest that the model‐based hemodynamic marker of DVR may correlate with cognitive impairment due to white matter lesions. This finding is consistent with the hypothesis that dysregulation of cerebral microcirculation may be an early cause of cognitive impairment, which has been recently corroborated by several studies. |
topic |
Alzheimer's disease cerebral flow regulation diffusion tensor imaging hemodynamic physiomarkers mild cognitive impairment model‐based diagnostic physiomarkers |
url |
https://doi.org/10.1002/brb3.1356 |
work_keys_str_mv |
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