White matter and its relationship with cognition in subjective cognitive decline
Abstract Introduction Subjective cognitive decline (SCD) is the earliest stage on the continuum toward Alzheimer's disease. This study examined (1) differences in white matter integrity between individuals with SCD and healthy control subjects and (2) how white matter integrity related to memor...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2019-12-01
|
Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
Subjects: | |
Online Access: | https://doi.org/10.1016/j.dadm.2018.10.008 |
id |
doaj-c3a5cf9f0f7a4082a6a62fbf057d8f44 |
---|---|
record_format |
Article |
spelling |
doaj-c3a5cf9f0f7a4082a6a62fbf057d8f442020-11-25T03:24:43ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292019-12-01111283510.1016/j.dadm.2018.10.008White matter and its relationship with cognition in subjective cognitive declineLisa Ohlhauser0Ashleigh F. Parker1Colette M. Smart2Jodie R. Gawryluk3Alzheimer's Disease Neuroimaging Initiative4Department of PsychologyUniversity of VictoriaVictoriaBritish ColumbiaCanadaDepartment of PsychologyUniversity of VictoriaVictoriaBritish ColumbiaCanadaDepartment of PsychologyUniversity of VictoriaVictoriaBritish ColumbiaCanadaDepartment of PsychologyUniversity of VictoriaVictoriaBritish ColumbiaCanadaDepartment of PsychologyUniversity of VictoriaVictoriaBritish ColumbiaCanadaAbstract Introduction Subjective cognitive decline (SCD) is the earliest stage on the continuum toward Alzheimer's disease. This study examined (1) differences in white matter integrity between individuals with SCD and healthy control subjects and (2) how white matter integrity related to memory and executive function. Methods Diffusion tensor imaging and neuropsychological assessment data were retrieved from the Alzheimer's Disease Neuroimaging Initiative database for 30 individuals with SCD and 44 control subjects. Results Results revealed significantly lower white matter integrity in individuals with SCD relative to control subjects in widespread regions, including the bilateral corticospinal tracts, superior and inferior longitudinal fasciculi, fronto‐occipital fasciculi, corpus callosum, forceps major and minor, hippocampi, anterior thalamic radiations, and the cerebellum. There was a widespread relationship between diffusion tensor imaging metrics and executive function in SCD, but not healthy control subjects, and no relationship with memory for either group. Discussion Relatively lower white matter integrity in SCD may be a useful early biomarker for risk of future cognitive decline. Future research should better characterize the SCD group longitudinally and in individuals at risk for Alzheimer's disease.https://doi.org/10.1016/j.dadm.2018.10.008Subjective cognitive declineDiffusion tensor imagingExecutive functionMemoryAlzheimer's disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lisa Ohlhauser Ashleigh F. Parker Colette M. Smart Jodie R. Gawryluk Alzheimer's Disease Neuroimaging Initiative |
spellingShingle |
Lisa Ohlhauser Ashleigh F. Parker Colette M. Smart Jodie R. Gawryluk Alzheimer's Disease Neuroimaging Initiative White matter and its relationship with cognition in subjective cognitive decline Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Subjective cognitive decline Diffusion tensor imaging Executive function Memory Alzheimer's disease |
author_facet |
Lisa Ohlhauser Ashleigh F. Parker Colette M. Smart Jodie R. Gawryluk Alzheimer's Disease Neuroimaging Initiative |
author_sort |
Lisa Ohlhauser |
title |
White matter and its relationship with cognition in subjective cognitive decline |
title_short |
White matter and its relationship with cognition in subjective cognitive decline |
title_full |
White matter and its relationship with cognition in subjective cognitive decline |
title_fullStr |
White matter and its relationship with cognition in subjective cognitive decline |
title_full_unstemmed |
White matter and its relationship with cognition in subjective cognitive decline |
title_sort |
white matter and its relationship with cognition in subjective cognitive decline |
publisher |
Wiley |
series |
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
issn |
2352-8729 |
publishDate |
2019-12-01 |
description |
Abstract Introduction Subjective cognitive decline (SCD) is the earliest stage on the continuum toward Alzheimer's disease. This study examined (1) differences in white matter integrity between individuals with SCD and healthy control subjects and (2) how white matter integrity related to memory and executive function. Methods Diffusion tensor imaging and neuropsychological assessment data were retrieved from the Alzheimer's Disease Neuroimaging Initiative database for 30 individuals with SCD and 44 control subjects. Results Results revealed significantly lower white matter integrity in individuals with SCD relative to control subjects in widespread regions, including the bilateral corticospinal tracts, superior and inferior longitudinal fasciculi, fronto‐occipital fasciculi, corpus callosum, forceps major and minor, hippocampi, anterior thalamic radiations, and the cerebellum. There was a widespread relationship between diffusion tensor imaging metrics and executive function in SCD, but not healthy control subjects, and no relationship with memory for either group. Discussion Relatively lower white matter integrity in SCD may be a useful early biomarker for risk of future cognitive decline. Future research should better characterize the SCD group longitudinally and in individuals at risk for Alzheimer's disease. |
topic |
Subjective cognitive decline Diffusion tensor imaging Executive function Memory Alzheimer's disease |
url |
https://doi.org/10.1016/j.dadm.2018.10.008 |
work_keys_str_mv |
AT lisaohlhauser whitematteranditsrelationshipwithcognitioninsubjectivecognitivedecline AT ashleighfparker whitematteranditsrelationshipwithcognitioninsubjectivecognitivedecline AT colettemsmart whitematteranditsrelationshipwithcognitioninsubjectivecognitivedecline AT jodiergawryluk whitematteranditsrelationshipwithcognitioninsubjectivecognitivedecline AT alzheimersdiseaseneuroimaginginitiative whitematteranditsrelationshipwithcognitioninsubjectivecognitivedecline |
_version_ |
1724600298486366208 |