Probiotics, Prebiotics and Postbiotics on Mitigation of Depression Symptoms: Modulation of the Brain–Gut–Microbiome Axis

The brain–gut–microbiome axis is a bidirectional communication pathway between the gut microbiota and the central nervous system. The growing interest in the gut microbiota and mechanisms of its interaction with the brain has contributed to the considerable attention given to the potential use of pr...

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Main Authors:	Agata Chudzik, Anna Orzyłowska, Radosław Rola, Greg J. Stanisz
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Series:	Biomolecules
Subjects:	microbiota brain–gut–microbiome axis depression probiotics prebiotics postbiotics
Online Access:	https://www.mdpi.com/2218-273X/11/7/1000

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spelling	doaj-c3a8ff20b1b14fbfb391bf9aef1251e52021-07-23T13:32:11ZengMDPI AGBiomolecules2218-273X2021-07-01111000100010.3390/biom11071000Probiotics, Prebiotics and Postbiotics on Mitigation of Depression Symptoms: Modulation of the Brain–Gut–Microbiome AxisAgata Chudzik0Anna Orzyłowska1Radosław Rola2Greg J. Stanisz3Department of Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, PolandDepartment of Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, PolandDepartment of Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, PolandDepartment of Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, PolandThe brain–gut–microbiome axis is a bidirectional communication pathway between the gut microbiota and the central nervous system. The growing interest in the gut microbiota and mechanisms of its interaction with the brain has contributed to the considerable attention given to the potential use of probiotics, prebiotics and postbiotics in the prevention and treatment of depressive disorders. This review discusses the up-to-date findings in preclinical and clinical trials regarding the use of pro-, pre- and postbiotics in depressive disorders. Studies in rodent models of depression show that some of them inhibit inflammation, decrease corticosterone level and change the level of neurometabolites, which consequently lead to mitigation of the symptoms of depression. Moreover, certain clinical studies have indicated improvement in mood as well as changes in biochemical parameters in patients suffering from depressive disorders.https://www.mdpi.com/2218-273X/11/7/1000microbiotabrain–gut–microbiome axisdepressionprobioticsprebioticspostbiotics
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Agata Chudzik Anna Orzyłowska Radosław Rola Greg J. Stanisz
spellingShingle	Agata Chudzik Anna Orzyłowska Radosław Rola Greg J. Stanisz Probiotics, Prebiotics and Postbiotics on Mitigation of Depression Symptoms: Modulation of the Brain–Gut–Microbiome Axis Biomolecules microbiota brain–gut–microbiome axis depression probiotics prebiotics postbiotics
author_facet	Agata Chudzik Anna Orzyłowska Radosław Rola Greg J. Stanisz
author_sort	Agata Chudzik
title	Probiotics, Prebiotics and Postbiotics on Mitigation of Depression Symptoms: Modulation of the Brain–Gut–Microbiome Axis
title_short	Probiotics, Prebiotics and Postbiotics on Mitigation of Depression Symptoms: Modulation of the Brain–Gut–Microbiome Axis
title_full	Probiotics, Prebiotics and Postbiotics on Mitigation of Depression Symptoms: Modulation of the Brain–Gut–Microbiome Axis
title_fullStr	Probiotics, Prebiotics and Postbiotics on Mitigation of Depression Symptoms: Modulation of the Brain–Gut–Microbiome Axis
title_full_unstemmed	Probiotics, Prebiotics and Postbiotics on Mitigation of Depression Symptoms: Modulation of the Brain–Gut–Microbiome Axis
title_sort	probiotics, prebiotics and postbiotics on mitigation of depression symptoms: modulation of the brain–gut–microbiome axis
publisher	MDPI AG
series	Biomolecules
issn	2218-273X
publishDate	2021-07-01
description	The brain–gut–microbiome axis is a bidirectional communication pathway between the gut microbiota and the central nervous system. The growing interest in the gut microbiota and mechanisms of its interaction with the brain has contributed to the considerable attention given to the potential use of probiotics, prebiotics and postbiotics in the prevention and treatment of depressive disorders. This review discusses the up-to-date findings in preclinical and clinical trials regarding the use of pro-, pre- and postbiotics in depressive disorders. Studies in rodent models of depression show that some of them inhibit inflammation, decrease corticosterone level and change the level of neurometabolites, which consequently lead to mitigation of the symptoms of depression. Moreover, certain clinical studies have indicated improvement in mood as well as changes in biochemical parameters in patients suffering from depressive disorders.
topic	microbiota brain–gut–microbiome axis depression probiotics prebiotics postbiotics
url	https://www.mdpi.com/2218-273X/11/7/1000
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Probiotics, Prebiotics and Postbiotics on Mitigation of Depression Symptoms: Modulation of the Brain–Gut–Microbiome Axis

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