Elevated Pretreatment Fibrinogen-to-Lymphocyte Percentage Ratio Predict Tumor Staging and Poor Survival in Non-Small Cell Lung Cancer Patients with Chemotherapy or Surgery Combined with Chemotherapy
Meifang Liu, Jie Yang, Lagen Wan, Rui Zhao Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of ChinaCorrespondence: Lagen Wan; Rui ZhaoDepartment of Clinical Laboratory, The First Affiliated Hospital of Na...
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doaj-c3e3fe63fd7e4258a73a813df15b258f2021-06-24T22:41:49ZengDove Medical PressCancer Management and Research1179-13222021-06-01Volume 134921493366082Elevated Pretreatment Fibrinogen-to-Lymphocyte Percentage Ratio Predict Tumor Staging and Poor Survival in Non-Small Cell Lung Cancer Patients with Chemotherapy or Surgery Combined with ChemotherapyLiu MYang JWan LZhao RMeifang Liu, Jie Yang, Lagen Wan, Rui Zhao Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of ChinaCorrespondence: Lagen Wan; Rui ZhaoDepartment of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of ChinaTel +86 79188693136Fax +86 79188692272Email WLGME196412@126.com; zhaoruisc@163.comPurpose: The objective of our study was to assess the association between lymphocyte percentage (LY%), fibrinogen (FIB), fibrinogen-to-lymphocyte percentage ratio (FLR) and the tumor staging and the clinical outcome role in non-small cell lung cancer (NSCLC) patients with chemotherapy or surgery combined with chemotherapy.Patients and Methods: Between August 2013 and October 2020, 375 patients initially diagnosed with NSCLC and 201 healthy subjects were enrolled in the retrospective study. The concentrations of LY%, FIB, and FLR were compared between the case group and the control group by using the Mann–Whitney U-test or Kruskal–Wallis test, and then these biomarkers were compared in terms of the tumor category and PTNM stage of the test group, etc. The cutoffs of LY%, FIB, and FLR were determined using X-tile software. The prognostic roles of LY%, FIB, and FLR were identified by the Kaplan–Meier curve and Cox regression model. The biological markers on overall survival (OS) were analyzed.Results: The study showed that the concentration levels of LY%, FIB, and FLR in the stage III–IV group were significant difference from those in the stage I–II group (P< 0.001), indicating that three biomarkers (LY%, FIB, and FLR) were significantly correlated with tumor staging. Pretreatment high FIB and FLR and low LY% indicated an increased risk of death in NSCLC patients. Also, it was found that the clinical outcome of low FLR patients with chemotherapy or chemotherapy combined with surgery was superior to high FLR patients.Conclusion: Our findings demonstrated that FLR could be used to predict NSCLC staging and was an independent prognosis factor within NSCLC patients receiving chemotherapy or chemotherapy combined with surgery.Keywords: fibrinogen-to-lymphocyte percentage ratio, lymphocyte percentage, fibrinogen, non-small-cell lung cancer, overall survivalhttps://www.dovepress.com/elevated-pretreatment-fibrinogen-to-lymphocyte-percentage-ratio-predic-peer-reviewed-fulltext-article-CMARlymphocyte percentagefibrinogennon-small-cell lung canceroverall survival |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Liu M Yang J Wan L Zhao R |
spellingShingle |
Liu M Yang J Wan L Zhao R Elevated Pretreatment Fibrinogen-to-Lymphocyte Percentage Ratio Predict Tumor Staging and Poor Survival in Non-Small Cell Lung Cancer Patients with Chemotherapy or Surgery Combined with Chemotherapy Cancer Management and Research lymphocyte percentage fibrinogen non-small-cell lung cancer overall survival |
author_facet |
Liu M Yang J Wan L Zhao R |
author_sort |
Liu M |
title |
Elevated Pretreatment Fibrinogen-to-Lymphocyte Percentage Ratio Predict Tumor Staging and Poor Survival in Non-Small Cell Lung Cancer Patients with Chemotherapy or Surgery Combined with Chemotherapy |
title_short |
Elevated Pretreatment Fibrinogen-to-Lymphocyte Percentage Ratio Predict Tumor Staging and Poor Survival in Non-Small Cell Lung Cancer Patients with Chemotherapy or Surgery Combined with Chemotherapy |
title_full |
Elevated Pretreatment Fibrinogen-to-Lymphocyte Percentage Ratio Predict Tumor Staging and Poor Survival in Non-Small Cell Lung Cancer Patients with Chemotherapy or Surgery Combined with Chemotherapy |
title_fullStr |
Elevated Pretreatment Fibrinogen-to-Lymphocyte Percentage Ratio Predict Tumor Staging and Poor Survival in Non-Small Cell Lung Cancer Patients with Chemotherapy or Surgery Combined with Chemotherapy |
title_full_unstemmed |
Elevated Pretreatment Fibrinogen-to-Lymphocyte Percentage Ratio Predict Tumor Staging and Poor Survival in Non-Small Cell Lung Cancer Patients with Chemotherapy or Surgery Combined with Chemotherapy |
title_sort |
elevated pretreatment fibrinogen-to-lymphocyte percentage ratio predict tumor staging and poor survival in non-small cell lung cancer patients with chemotherapy or surgery combined with chemotherapy |
publisher |
Dove Medical Press |
series |
Cancer Management and Research |
issn |
1179-1322 |
publishDate |
2021-06-01 |
description |
Meifang Liu, Jie Yang, Lagen Wan, Rui Zhao Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of ChinaCorrespondence: Lagen Wan; Rui ZhaoDepartment of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of ChinaTel +86 79188693136Fax +86 79188692272Email WLGME196412@126.com; zhaoruisc@163.comPurpose: The objective of our study was to assess the association between lymphocyte percentage (LY%), fibrinogen (FIB), fibrinogen-to-lymphocyte percentage ratio (FLR) and the tumor staging and the clinical outcome role in non-small cell lung cancer (NSCLC) patients with chemotherapy or surgery combined with chemotherapy.Patients and Methods: Between August 2013 and October 2020, 375 patients initially diagnosed with NSCLC and 201 healthy subjects were enrolled in the retrospective study. The concentrations of LY%, FIB, and FLR were compared between the case group and the control group by using the Mann–Whitney U-test or Kruskal–Wallis test, and then these biomarkers were compared in terms of the tumor category and PTNM stage of the test group, etc. The cutoffs of LY%, FIB, and FLR were determined using X-tile software. The prognostic roles of LY%, FIB, and FLR were identified by the Kaplan–Meier curve and Cox regression model. The biological markers on overall survival (OS) were analyzed.Results: The study showed that the concentration levels of LY%, FIB, and FLR in the stage III–IV group were significant difference from those in the stage I–II group (P< 0.001), indicating that three biomarkers (LY%, FIB, and FLR) were significantly correlated with tumor staging. Pretreatment high FIB and FLR and low LY% indicated an increased risk of death in NSCLC patients. Also, it was found that the clinical outcome of low FLR patients with chemotherapy or chemotherapy combined with surgery was superior to high FLR patients.Conclusion: Our findings demonstrated that FLR could be used to predict NSCLC staging and was an independent prognosis factor within NSCLC patients receiving chemotherapy or chemotherapy combined with surgery.Keywords: fibrinogen-to-lymphocyte percentage ratio, lymphocyte percentage, fibrinogen, non-small-cell lung cancer, overall survival |
topic |
lymphocyte percentage fibrinogen non-small-cell lung cancer overall survival |
url |
https://www.dovepress.com/elevated-pretreatment-fibrinogen-to-lymphocyte-percentage-ratio-predic-peer-reviewed-fulltext-article-CMAR |
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