Tff3, as a novel peptide, regulates hepatic glucose metabolism.
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder strongly associated with hepatic glucose intolerance and insulin resistance. The trefoil peptides are a family of small regulatory proteins and Tff3 is widely expressed in multiple tissues including liver. But the roles of Tff3 in regul...
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doaj-c3ee7491d0c4442b9b2291f6ef20b07e2020-11-25T02:29:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7524010.1371/journal.pone.0075240Tff3, as a novel peptide, regulates hepatic glucose metabolism.Yuan XueLian ShenYing CuiHuabing ZhangQi ChenAnfang CuiFude FangYongsheng ChangType 2 diabetes mellitus (T2DM) is a chronic metabolic disorder strongly associated with hepatic glucose intolerance and insulin resistance. The trefoil peptides are a family of small regulatory proteins and Tff3 is widely expressed in multiple tissues including liver. But the roles of Tff3 in regulation of glucose metabolism and insulin sensitivity in liver remain unclear. Here we show that the hepatic Tff3 expression levels were decreased in ob/ob and high-fat diet-induced obese mice. Overexpression of Tff3 in primary mouse hepatocytes inhibited the expression of gluconeogenic genes, including G6pc, PEPCK and PGC-1α, subsequently decreasing cellular glucose output. GTT and ITT experiments revealed that adenovirus-mediated overexpression of Tff3 in diabetic or obese mice improved glucose tolerance and insulin sensitivity. Collectively, our results indicated that Tff3 peptides are involved in glucose homeostasis and insulin sensitivity, providing a promising peptide on new therapies against the metabolic disorders associated with T2DM.http://europepmc.org/articles/PMC3781022?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuan Xue Lian Shen Ying Cui Huabing Zhang Qi Chen Anfang Cui Fude Fang Yongsheng Chang |
spellingShingle |
Yuan Xue Lian Shen Ying Cui Huabing Zhang Qi Chen Anfang Cui Fude Fang Yongsheng Chang Tff3, as a novel peptide, regulates hepatic glucose metabolism. PLoS ONE |
author_facet |
Yuan Xue Lian Shen Ying Cui Huabing Zhang Qi Chen Anfang Cui Fude Fang Yongsheng Chang |
author_sort |
Yuan Xue |
title |
Tff3, as a novel peptide, regulates hepatic glucose metabolism. |
title_short |
Tff3, as a novel peptide, regulates hepatic glucose metabolism. |
title_full |
Tff3, as a novel peptide, regulates hepatic glucose metabolism. |
title_fullStr |
Tff3, as a novel peptide, regulates hepatic glucose metabolism. |
title_full_unstemmed |
Tff3, as a novel peptide, regulates hepatic glucose metabolism. |
title_sort |
tff3, as a novel peptide, regulates hepatic glucose metabolism. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder strongly associated with hepatic glucose intolerance and insulin resistance. The trefoil peptides are a family of small regulatory proteins and Tff3 is widely expressed in multiple tissues including liver. But the roles of Tff3 in regulation of glucose metabolism and insulin sensitivity in liver remain unclear. Here we show that the hepatic Tff3 expression levels were decreased in ob/ob and high-fat diet-induced obese mice. Overexpression of Tff3 in primary mouse hepatocytes inhibited the expression of gluconeogenic genes, including G6pc, PEPCK and PGC-1α, subsequently decreasing cellular glucose output. GTT and ITT experiments revealed that adenovirus-mediated overexpression of Tff3 in diabetic or obese mice improved glucose tolerance and insulin sensitivity. Collectively, our results indicated that Tff3 peptides are involved in glucose homeostasis and insulin sensitivity, providing a promising peptide on new therapies against the metabolic disorders associated with T2DM. |
url |
http://europepmc.org/articles/PMC3781022?pdf=render |
work_keys_str_mv |
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1724830676130201600 |