Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps
<p>Abstract</p> <p>Rapidly developing comparative gene maps in selected mammal species are providing an opportunity to reconstruct the genomic architecture of mammalian ancestors and study rearrangements that transformed this ancestral genome into existing mammalian genomes. Here,...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2003-11-01
|
Series: | Human Genomics |
Subjects: | |
Online Access: | http://www.humgenomics.com/content/1/1/30 |
id |
doaj-c3efe7ee177340d1ad5b617eb8704bc5 |
---|---|
record_format |
Article |
spelling |
doaj-c3efe7ee177340d1ad5b617eb8704bc52020-11-25T00:04:48ZengBMCHuman Genomics1479-73642003-11-0111304010.1186/1479-7364-1-1-30Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative mapsMurphy William JBourque GuillaumeTesler GlennPevzner PavelO'Brien Stephen J<p>Abstract</p> <p>Rapidly developing comparative gene maps in selected mammal species are providing an opportunity to reconstruct the genomic architecture of mammalian ancestors and study rearrangements that transformed this ancestral genome into existing mammalian genomes. Here, the recently developed Multiple Genome Rearrangement (MGR) algorithm is applied to human, mouse, cat and cattle comparative maps (with 311-470 shared markers) to impute the ancestral mammalian genome. Reconstructed ancestors consist of 70-100 conserved segments shared across the genomes that have been exchanged by rearrangement events along the ordinal lineages leading to modern species genomes. Genomic distances between species, dominated by inversions (reversals) and translocations, are presented in a first multispecies attempt using ordered mapping data to reconstruct the evolutionary exchanges that preceded modern placental mammal genomes.</p> http://www.humgenomics.com/content/1/1/30genome evolutionsyntenymammalsancestral genome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Murphy William J Bourque Guillaume Tesler Glenn Pevzner Pavel O'Brien Stephen J |
spellingShingle |
Murphy William J Bourque Guillaume Tesler Glenn Pevzner Pavel O'Brien Stephen J Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps Human Genomics genome evolution synteny mammals ancestral genome |
author_facet |
Murphy William J Bourque Guillaume Tesler Glenn Pevzner Pavel O'Brien Stephen J |
author_sort |
Murphy William J |
title |
Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps |
title_short |
Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps |
title_full |
Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps |
title_fullStr |
Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps |
title_full_unstemmed |
Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps |
title_sort |
reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps |
publisher |
BMC |
series |
Human Genomics |
issn |
1479-7364 |
publishDate |
2003-11-01 |
description |
<p>Abstract</p> <p>Rapidly developing comparative gene maps in selected mammal species are providing an opportunity to reconstruct the genomic architecture of mammalian ancestors and study rearrangements that transformed this ancestral genome into existing mammalian genomes. Here, the recently developed Multiple Genome Rearrangement (MGR) algorithm is applied to human, mouse, cat and cattle comparative maps (with 311-470 shared markers) to impute the ancestral mammalian genome. Reconstructed ancestors consist of 70-100 conserved segments shared across the genomes that have been exchanged by rearrangement events along the ordinal lineages leading to modern species genomes. Genomic distances between species, dominated by inversions (reversals) and translocations, are presented in a first multispecies attempt using ordered mapping data to reconstruct the evolutionary exchanges that preceded modern placental mammal genomes.</p> |
topic |
genome evolution synteny mammals ancestral genome |
url |
http://www.humgenomics.com/content/1/1/30 |
work_keys_str_mv |
AT murphywilliamj reconstructingthegenomicarchitectureofmammalianancestorsusingmultispeciescomparativemaps AT bourqueguillaume reconstructingthegenomicarchitectureofmammalianancestorsusingmultispeciescomparativemaps AT teslerglenn reconstructingthegenomicarchitectureofmammalianancestorsusingmultispeciescomparativemaps AT pevznerpavel reconstructingthegenomicarchitectureofmammalianancestorsusingmultispeciescomparativemaps AT obrienstephenj reconstructingthegenomicarchitectureofmammalianancestorsusingmultispeciescomparativemaps |
_version_ |
1725427936315572224 |