Inducible Nitric Oxide Synthase Genetic Polymorphism and Risk of Asbestosis
Asbestos, a known occupational pollutant, may upregulate the activity of inducible nitric oxide synthase (iNOS) and thus the production of nitric oxide (NO). This study investigated whether iNOS (CCTTT)n polymorphism is associated with an increased asbestosis risk in exposed workers. The study coho...
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doaj-c3f313391caa49f5bf69b5a61318738b2020-11-24T21:31:44ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512011-01-01201110.1155/2011/685870685870Inducible Nitric Oxide Synthase Genetic Polymorphism and Risk of AsbestosisAlenka Franko0Metoda Dodič-Fikfak1Niko Arnerić2Vita Dolžan3Clinical Institute of Occupational Medicine, University Medical Center, Poljanski Nasip 58, 1000 Ljubljana, SloveniaClinical Institute of Occupational Medicine, University Medical Center, Poljanski Nasip 58, 1000 Ljubljana, SloveniaClinical Institute of Occupational Medicine, University Medical Center, Poljanski Nasip 58, 1000 Ljubljana, SloveniaInstitute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, SloveniaAsbestos, a known occupational pollutant, may upregulate the activity of inducible nitric oxide synthase (iNOS) and thus the production of nitric oxide (NO). This study investigated whether iNOS (CCTTT)n polymorphism is associated with an increased asbestosis risk in exposed workers. The study cohort consisted of 262 cases with asbestosis and 265 controls with no asbestos-related disease. For each subject the cumulative asbestos exposure data were available. The number of CCTTT repeats was determined following PCR amplification of the iNOS promoter region. Logistic regression was performed to estimate asbestosis risk. The OR of asbestosis was 1.20 (95% CI = 0.85–1.69) for the LL genotype compared to the combined SL and SS genotypes and 1.26 (95% CI = 0.86–1.85) for the LL genotype compared to the SL genotype. The results of this study are borderline significant and suggest a possible role of iNOS (CCTTT)n polymorphism in the risk of asbestosis; however, further studies are needed.http://dx.doi.org/10.1155/2011/685870 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alenka Franko Metoda Dodič-Fikfak Niko Arnerić Vita Dolžan |
spellingShingle |
Alenka Franko Metoda Dodič-Fikfak Niko Arnerić Vita Dolžan Inducible Nitric Oxide Synthase Genetic Polymorphism and Risk of Asbestosis Journal of Biomedicine and Biotechnology |
author_facet |
Alenka Franko Metoda Dodič-Fikfak Niko Arnerić Vita Dolžan |
author_sort |
Alenka Franko |
title |
Inducible Nitric Oxide Synthase Genetic Polymorphism and Risk of Asbestosis |
title_short |
Inducible Nitric Oxide Synthase Genetic Polymorphism and Risk of Asbestosis |
title_full |
Inducible Nitric Oxide Synthase Genetic Polymorphism and Risk of Asbestosis |
title_fullStr |
Inducible Nitric Oxide Synthase Genetic Polymorphism and Risk of Asbestosis |
title_full_unstemmed |
Inducible Nitric Oxide Synthase Genetic Polymorphism and Risk of Asbestosis |
title_sort |
inducible nitric oxide synthase genetic polymorphism and risk of asbestosis |
publisher |
Hindawi Limited |
series |
Journal of Biomedicine and Biotechnology |
issn |
1110-7243 1110-7251 |
publishDate |
2011-01-01 |
description |
Asbestos, a known occupational pollutant, may upregulate the activity of inducible nitric oxide synthase (iNOS) and thus the production of nitric oxide (NO). This study investigated whether iNOS (CCTTT)n polymorphism is associated with an increased asbestosis risk in exposed workers.
The study cohort consisted of 262 cases with asbestosis and 265 controls with no asbestos-related disease. For each subject the cumulative asbestos exposure data were available. The number of CCTTT repeats was determined following PCR amplification of the iNOS promoter region. Logistic regression was performed to estimate asbestosis risk.
The OR of asbestosis was 1.20 (95% CI = 0.85–1.69) for the LL genotype compared to the combined SL and SS genotypes and 1.26 (95% CI = 0.86–1.85) for the LL genotype compared to the SL genotype.
The results of this study are borderline significant and suggest a possible role of iNOS (CCTTT)n polymorphism in the risk of asbestosis; however, further studies are needed. |
url |
http://dx.doi.org/10.1155/2011/685870 |
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