Reproducibility of Variant Calls in Replicate Next Generation Sequencing Experiments.

Reproducibility of Variant Calls in Replicate Next Generation Sequencing Experiments.

Nucleotide alterations detected by next generation sequencing are not always true biological changes but could represent sequencing errors. Even highly accurate methods can yield substantial error rates when applied to millions of nucleotides. In this study, we examined the reproducibility of nucleo...

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Bibliographic Details
Main Authors: Yuan Qi, Xiuping Liu, Chang-Gong Liu, Bailing Wang, Kenneth R Hess, W Fraser Symmans, Weiwei Shi, Lajos Pusztai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4489803?pdf=render

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