Long-Term Follow-Up of a Portuguese Single-Centre Cohort of Persons with Haemophilia and Hepatitis C Virus Infection
Introduction: Persons with haemophilia (PWH) used to represent a population with a high prevalence of hepatitis C virus (HCV) infection due to the use of contaminated blood products. Although the goals of antiviral therapy are the same as the general population, long real-life follow-up data regardi...
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doaj-c426318c96bc4770b86553f51c048e742020-11-25T03:36:58ZengKarger PublishersGE: Portuguese Journal of Gastroenterology2341-45452387-19542020-09-011810.1159/000510023510023Long-Term Follow-Up of a Portuguese Single-Centre Cohort of Persons with Haemophilia and Hepatitis C Virus InfectionTiago Pereira GuedesMónica GarridoRicardo Kuttner MagalhãesTeresa MoreiraMarta RochaLuís MaiaJosé Manuel FerreiraSara MoraisIsabel PedrotoIntroduction: Persons with haemophilia (PWH) used to represent a population with a high prevalence of hepatitis C virus (HCV) infection due to the use of contaminated blood products. Although the goals of antiviral therapy are the same as the general population, long real-life follow-up data regarding their outcomes are still scarce. Our aim was to report the outcomes of HCV infection and the results of antiviral therapy in PWH. Methods: A retrospective analysis was performed in a single-centre cohort of PWH with positive HCV antibody. Outcomes registered were rate of spontaneous clearance of HCV, sustained virologic response (SVR) achievement, development of end-stage liver disease, and all-cause and liver-related mortality. Results: Out of 131 PWH, 73 (55.7%) had positive HCV antibody. During a median follow-up time of 22 years, 46 patients (63.9%) developed chronic hepatitis C, of which 16 (34.8%) developed cirrhosis. Treatment was pursued in 34 PWH. Most (n = 32) were first treated with interferon (IFN)-based regimens with SVR rates of 40.6%. Direct-acting antivirals were used in 14 IFN-experienced and 2 naïve patients, with an overall SVR rate of 100%. Overall, 17 patients (23.3%) died during the follow-up, only 4 related to liver disease. Of these, none had achieved SVR. Conclusions: We describe the outcomes of a cohort of Portuguese PWH and hepatitis C exposure after two decades of follow-up, with a lower mortality than previously described. Our response rates to HCV treatment were comparable to those in the general population and stress the importance of early treatment.https://www.karger.com/Article/FullText/510023hepatitis c, chronichaemophilia ahaemophilia bend-stage liver diseasedirect-acting antivirals |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tiago Pereira Guedes Mónica Garrido Ricardo Kuttner Magalhães Teresa Moreira Marta Rocha Luís Maia José Manuel Ferreira Sara Morais Isabel Pedroto |
spellingShingle |
Tiago Pereira Guedes Mónica Garrido Ricardo Kuttner Magalhães Teresa Moreira Marta Rocha Luís Maia José Manuel Ferreira Sara Morais Isabel Pedroto Long-Term Follow-Up of a Portuguese Single-Centre Cohort of Persons with Haemophilia and Hepatitis C Virus Infection GE: Portuguese Journal of Gastroenterology hepatitis c, chronic haemophilia a haemophilia b end-stage liver disease direct-acting antivirals |
author_facet |
Tiago Pereira Guedes Mónica Garrido Ricardo Kuttner Magalhães Teresa Moreira Marta Rocha Luís Maia José Manuel Ferreira Sara Morais Isabel Pedroto |
author_sort |
Tiago Pereira Guedes |
title |
Long-Term Follow-Up of a Portuguese Single-Centre Cohort of Persons with Haemophilia and Hepatitis C Virus Infection |
title_short |
Long-Term Follow-Up of a Portuguese Single-Centre Cohort of Persons with Haemophilia and Hepatitis C Virus Infection |
title_full |
Long-Term Follow-Up of a Portuguese Single-Centre Cohort of Persons with Haemophilia and Hepatitis C Virus Infection |
title_fullStr |
Long-Term Follow-Up of a Portuguese Single-Centre Cohort of Persons with Haemophilia and Hepatitis C Virus Infection |
title_full_unstemmed |
Long-Term Follow-Up of a Portuguese Single-Centre Cohort of Persons with Haemophilia and Hepatitis C Virus Infection |
title_sort |
long-term follow-up of a portuguese single-centre cohort of persons with haemophilia and hepatitis c virus infection |
publisher |
Karger Publishers |
series |
GE: Portuguese Journal of Gastroenterology |
issn |
2341-4545 2387-1954 |
publishDate |
2020-09-01 |
description |
Introduction: Persons with haemophilia (PWH) used to represent a population with a high prevalence of hepatitis C virus (HCV) infection due to the use of contaminated blood products. Although the goals of antiviral therapy are the same as the general population, long real-life follow-up data regarding their outcomes are still scarce. Our aim was to report the outcomes of HCV infection and the results of antiviral therapy in PWH. Methods: A retrospective analysis was performed in a single-centre cohort of PWH with positive HCV antibody. Outcomes registered were rate of spontaneous clearance of HCV, sustained virologic response (SVR) achievement, development of end-stage liver disease, and all-cause and liver-related mortality. Results: Out of 131 PWH, 73 (55.7%) had positive HCV antibody. During a median follow-up time of 22 years, 46 patients (63.9%) developed chronic hepatitis C, of which 16 (34.8%) developed cirrhosis. Treatment was pursued in 34 PWH. Most (n = 32) were first treated with interferon (IFN)-based regimens with SVR rates of 40.6%. Direct-acting antivirals were used in 14 IFN-experienced and 2 naïve patients, with an overall SVR rate of 100%. Overall, 17 patients (23.3%) died during the follow-up, only 4 related to liver disease. Of these, none had achieved SVR. Conclusions: We describe the outcomes of a cohort of Portuguese PWH and hepatitis C exposure after two decades of follow-up, with a lower mortality than previously described. Our response rates to HCV treatment were comparable to those in the general population and stress the importance of early treatment. |
topic |
hepatitis c, chronic haemophilia a haemophilia b end-stage liver disease direct-acting antivirals |
url |
https://www.karger.com/Article/FullText/510023 |
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