Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6
Cerebral aneurysms are well known to be associated with cardiac myxomas. The mechanism of cerebral aneurysm formation remains to be elucidated. Embolization of tumor particles in the vessel wall has been proposed as the likely mechanism for aneurysm formation. Recent reports suggest interleukin-6 (I...
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doaj-c4264209418644d6a0b5ef380cfd0dd12020-11-24T23:03:33ZengKarger PublishersCase Reports in Neurology1662-680X2015-07-017215215510.1159/000437256437256Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6Nnadozie EzeriohaWuwei FengCerebral aneurysms are well known to be associated with cardiac myxomas. The mechanism of cerebral aneurysm formation remains to be elucidated. Embolization of tumor particles in the vessel wall has been proposed as the likely mechanism for aneurysm formation. Recent reports suggest interleukin-6 (IL-6) may play a role as well. We describe a patient who presented with subarachnoid hemorrhage secondary to ruptured right middle cerebral artery (MCA) aneurysm and unruptured left MCA aneurysm. Subsequently, the patient was found to have an atrial myxoma and persistently elevated serum IL-6 levels. Transcranial Doppler monitoring showed multiple emboli in the right MCA vascular territory on day 1 after surgery but no recurrent embolization during the next 2 weeks on repeated tests. Elevated IL-6 levels were noted both on day 1 and on day 30. Our findings provide evidence that IL-6 elevation and not tumor embolization is likely the culprit for aneurysm formation in some patients with atrial myxoma.http://www.karger.com/Article/FullText/437256Intracardiac myxomaCerebral aneurysmInterleukin-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nnadozie Ezerioha Wuwei Feng |
spellingShingle |
Nnadozie Ezerioha Wuwei Feng Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6 Case Reports in Neurology Intracardiac myxoma Cerebral aneurysm Interleukin-6 |
author_facet |
Nnadozie Ezerioha Wuwei Feng |
author_sort |
Nnadozie Ezerioha |
title |
Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6 |
title_short |
Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6 |
title_full |
Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6 |
title_fullStr |
Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6 |
title_full_unstemmed |
Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6 |
title_sort |
intracardiac myxoma, cerebral aneurysms and elevated interleukin-6 |
publisher |
Karger Publishers |
series |
Case Reports in Neurology |
issn |
1662-680X |
publishDate |
2015-07-01 |
description |
Cerebral aneurysms are well known to be associated with cardiac myxomas. The mechanism of cerebral aneurysm formation remains to be elucidated. Embolization of tumor particles in the vessel wall has been proposed as the likely mechanism for aneurysm formation. Recent reports suggest interleukin-6 (IL-6) may play a role as well. We describe a patient who presented with subarachnoid hemorrhage secondary to ruptured right middle cerebral artery (MCA) aneurysm and unruptured left MCA aneurysm. Subsequently, the patient was found to have an atrial myxoma and persistently elevated serum IL-6 levels. Transcranial Doppler monitoring showed multiple emboli in the right MCA vascular territory on day 1 after surgery but no recurrent embolization during the next 2 weeks on repeated tests. Elevated IL-6 levels were noted both on day 1 and on day 30. Our findings provide evidence that IL-6 elevation and not tumor embolization is likely the culprit for aneurysm formation in some patients with atrial myxoma. |
topic |
Intracardiac myxoma Cerebral aneurysm Interleukin-6 |
url |
http://www.karger.com/Article/FullText/437256 |
work_keys_str_mv |
AT nnadozieezerioha intracardiacmyxomacerebralaneurysmsandelevatedinterleukin6 AT wuweifeng intracardiacmyxomacerebralaneurysmsandelevatedinterleukin6 |
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