The importance of bone biopsy in chronic kidney disease–Mineral bone disorders
Renal osteodystrophy (ROD) is not a uniform bone disease; it is a heterogeneous group of metabolic bone diseases due to chronic kidney disease (CKD). The traditional term of ROD does not accurately include the wide spectrum of “CKD–mineral and bone disorder” (CKD–MBD) and has been restricted to defi...
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Wolters Kluwer Medknow Publications
2017-01-01
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Series: | Saudi Journal of Kidney Diseases and Transplantation |
Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2017;volume=28;issue=5;spage=992;epage=996;aulast=Dousdampanis |
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doaj-c42700c9dc39402fad7228b6d96d12d42020-11-24T23:15:06ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422017-01-0128599299610.4103/1319-2442.215150The importance of bone biopsy in chronic kidney disease–Mineral bone disordersPeriklis DousdampanisKostantina TrigkaRenal osteodystrophy (ROD) is not a uniform bone disease; it is a heterogeneous group of metabolic bone diseases due to chronic kidney disease (CKD). The traditional term of ROD does not accurately include the wide spectrum of “CKD–mineral and bone disorder” (CKD–MBD) and has been restricted to define the several specific histologic disturbances of bone disease associated with CKD. Circulating parathyroid hormone (PTH) and total alkaline phosphatase levels do not always reflect bone turnover in CKD–MBD, whereas bone biopsy provides precise information regarding bone pathology. Given the lack of specificity of several biomarkers and noninvasive tools regarding ROD, bone biopsy is required for precise diagnosis and for the determination of therapeutic strategies. In clinical practice, bone biopsy is not performed due to lack of enthusiasm among nephrologists for several reasons including the invasiveness of the procedure, the potential pain, and lack of technical training. Since the application of bone biopsy in clinical practice is unrealistic, several biomarkers with specificity for bone disease should be studied.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2017;volume=28;issue=5;spage=992;epage=996;aulast=Dousdampanis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Periklis Dousdampanis Kostantina Trigka |
spellingShingle |
Periklis Dousdampanis Kostantina Trigka The importance of bone biopsy in chronic kidney disease–Mineral bone disorders Saudi Journal of Kidney Diseases and Transplantation |
author_facet |
Periklis Dousdampanis Kostantina Trigka |
author_sort |
Periklis Dousdampanis |
title |
The importance of bone biopsy in chronic kidney disease–Mineral bone disorders |
title_short |
The importance of bone biopsy in chronic kidney disease–Mineral bone disorders |
title_full |
The importance of bone biopsy in chronic kidney disease–Mineral bone disorders |
title_fullStr |
The importance of bone biopsy in chronic kidney disease–Mineral bone disorders |
title_full_unstemmed |
The importance of bone biopsy in chronic kidney disease–Mineral bone disorders |
title_sort |
importance of bone biopsy in chronic kidney disease–mineral bone disorders |
publisher |
Wolters Kluwer Medknow Publications |
series |
Saudi Journal of Kidney Diseases and Transplantation |
issn |
1319-2442 |
publishDate |
2017-01-01 |
description |
Renal osteodystrophy (ROD) is not a uniform bone disease; it is a heterogeneous group of metabolic bone diseases due to chronic kidney disease (CKD). The traditional term of ROD does not accurately include the wide spectrum of “CKD–mineral and bone disorder” (CKD–MBD) and has been restricted to define the several specific histologic disturbances of bone disease associated with CKD. Circulating parathyroid hormone (PTH) and total alkaline phosphatase levels do not always reflect bone turnover in CKD–MBD, whereas bone biopsy provides precise information regarding bone pathology. Given the lack of specificity of several biomarkers and noninvasive tools regarding ROD, bone biopsy is required for precise diagnosis and for the determination of therapeutic strategies. In clinical practice, bone biopsy is not performed due to lack of enthusiasm among nephrologists for several reasons including the invasiveness of the procedure, the potential pain, and lack of technical training. Since the application of bone biopsy in clinical practice is unrealistic, several biomarkers with specificity for bone disease should be studied. |
url |
http://www.sjkdt.org/article.asp?issn=1319-2442;year=2017;volume=28;issue=5;spage=992;epage=996;aulast=Dousdampanis |
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