| Summary: | <p class="p p-first-last" id="__p2">The objective of the present study was to investigate the antibiotic susceptibility including mupirocin among <em>Staphylococcus. epidermidis</em> isolated from prosthetic joint infections (PJIs) (n=183) and nasal isolates (n=75) from patients intended to undergo prosthetic joint replacements. Susceptibility to mupirocin (used for eradication of nasal carriership of <em>Staphylococcus aureus</em>) was investigated by gradient test, and susceptibility to various other antimicrobial agents was investigated by disc diffusion test. All isolates, except three from PJIs and one from the nares, were fully susceptible to mupirocin. Multi-drug resistance (≥3 antibiotic classes) was found in 154/183 (84.2%) of the PJI isolates but only in 2/75 (2.7%) of the nares isolates, indicating that <em>S. epidermidis</em> causing PJIs do not originate from the nares.</p>
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