Circular RNA: an important player with multiple facets to regulate its parental gene expression
Circular RNAs (circRNAs), a novel type of endogenous RNAs with covalently closed-loop structures, have become a new research hotspot in the RNA world. Their diversity, stability, evolutionary conservation, and cell type- or tissue-specific expression patterns endow circRNAs with various important bi...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-03-01
|
Series: | Molecular Therapy: Nucleic Acids |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253120303644 |
id |
doaj-c4290db3464f4834b1d28c299deec5f0 |
---|---|
record_format |
Article |
spelling |
doaj-c4290db3464f4834b1d28c299deec5f02021-03-07T04:27:48ZengElsevierMolecular Therapy: Nucleic Acids2162-25312021-03-0123369376Circular RNA: an important player with multiple facets to regulate its parental gene expressionTong Shao0Yan-hong Pan1Xing-dong Xiong2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, P.R. China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, P.R. ChinaGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, P.R. China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, P.R. ChinaGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, P.R. China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, P.R. China; Corresponding author: Xing-dong Xiong, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Aging Research, Guangdong Medical University, Xin Cheng Avenue 1#, Songshan Lake, Dongguan 523808, P.R. China.Circular RNAs (circRNAs), a novel type of endogenous RNAs with covalently closed-loop structures, have become a new research hotspot in the RNA world. Their diversity, stability, evolutionary conservation, and cell type- or tissue-specific expression patterns endow circRNAs with various important biological functions. As a consequence, circRNAs are emerging as important regulators of physiological development and disease pathogenesis. Growing evidence has shown that circRNAs can regulate parental gene expression through diverse mechanisms, such as transcription and splicing regulation, microRNA (miRNA) sponges, mRNA traps, translational modulation, and post-translational modification. The study of circRNAs and how circRNAs regulate the expression of parental genes will facilitate a deeper understanding of their biological functions and provide new perspectives on their clinical application. Herein, we review the biogenesis of circRNAs, with a particular focus on the molecular mechanisms of circRNAs regulating their parental gene expression and the biological significance of such regulation.http://www.sciencedirect.com/science/article/pii/S2162253120303644circular RNAgene expressionparental generegulatory mechanism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tong Shao Yan-hong Pan Xing-dong Xiong |
spellingShingle |
Tong Shao Yan-hong Pan Xing-dong Xiong Circular RNA: an important player with multiple facets to regulate its parental gene expression Molecular Therapy: Nucleic Acids circular RNA gene expression parental gene regulatory mechanism |
author_facet |
Tong Shao Yan-hong Pan Xing-dong Xiong |
author_sort |
Tong Shao |
title |
Circular RNA: an important player with multiple facets to regulate its parental gene expression |
title_short |
Circular RNA: an important player with multiple facets to regulate its parental gene expression |
title_full |
Circular RNA: an important player with multiple facets to regulate its parental gene expression |
title_fullStr |
Circular RNA: an important player with multiple facets to regulate its parental gene expression |
title_full_unstemmed |
Circular RNA: an important player with multiple facets to regulate its parental gene expression |
title_sort |
circular rna: an important player with multiple facets to regulate its parental gene expression |
publisher |
Elsevier |
series |
Molecular Therapy: Nucleic Acids |
issn |
2162-2531 |
publishDate |
2021-03-01 |
description |
Circular RNAs (circRNAs), a novel type of endogenous RNAs with covalently closed-loop structures, have become a new research hotspot in the RNA world. Their diversity, stability, evolutionary conservation, and cell type- or tissue-specific expression patterns endow circRNAs with various important biological functions. As a consequence, circRNAs are emerging as important regulators of physiological development and disease pathogenesis. Growing evidence has shown that circRNAs can regulate parental gene expression through diverse mechanisms, such as transcription and splicing regulation, microRNA (miRNA) sponges, mRNA traps, translational modulation, and post-translational modification. The study of circRNAs and how circRNAs regulate the expression of parental genes will facilitate a deeper understanding of their biological functions and provide new perspectives on their clinical application. Herein, we review the biogenesis of circRNAs, with a particular focus on the molecular mechanisms of circRNAs regulating their parental gene expression and the biological significance of such regulation. |
topic |
circular RNA gene expression parental gene regulatory mechanism |
url |
http://www.sciencedirect.com/science/article/pii/S2162253120303644 |
work_keys_str_mv |
AT tongshao circularrnaanimportantplayerwithmultiplefacetstoregulateitsparentalgeneexpression AT yanhongpan circularrnaanimportantplayerwithmultiplefacetstoregulateitsparentalgeneexpression AT xingdongxiong circularrnaanimportantplayerwithmultiplefacetstoregulateitsparentalgeneexpression |
_version_ |
1724229443926360064 |