Structure, Activity and Function of the NSD3 Protein Lysine Methyltransferase

Structure, Activity and Function of the NSD3 Protein Lysine Methyltransferase

NSD3 is one of six H3K36-specific lysine methyltransferases in metazoans, and the methylation of H3K36 is associated with active transcription. NSD3 is a member of the nuclear receptor-binding SET domain (NSD) family of histone methyltransferases together with NSD1 and NSD2, which generate mono- and...

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Main Author: Philipp Rathert
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Life
Subjects:
NSD3
WHSC1L1
structure and function
Online Access:https://www.mdpi.com/2075-1729/11/8/726
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spelling doaj-c42d0288aa714386bef73813d5006b6f2021-08-26T13:58:54ZengMDPI AGLife2075-17292021-07-011172672610.3390/life11080726Structure, Activity and Function of the NSD3 Protein Lysine MethyltransferasePhilipp Rathert0Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, 70569 Stuttgart, GermanyNSD3 is one of six H3K36-specific lysine methyltransferases in metazoans, and the methylation of H3K36 is associated with active transcription. NSD3 is a member of the nuclear receptor-binding SET domain (NSD) family of histone methyltransferases together with NSD1 and NSD2, which generate mono- and dimethylated lysine on histone H3. NSD3 is mutated and hyperactive in some human cancers, but the biochemical mechanisms underlying such dysregulation are barely understood. In this review, the current knowledge of NSD3 is systematically reviewed. Finally, the molecular and functional characteristics of NSD3 in different tumor types according to the current research are summarized.https://www.mdpi.com/2075-1729/11/8/726NSD3WHSC1L1structure and function
collection DOAJ
language English
format Article
sources DOAJ
author Philipp Rathert
spellingShingle Philipp Rathert
Structure, Activity and Function of the NSD3 Protein Lysine Methyltransferase
Life
NSD3
WHSC1L1
structure and function
author_facet Philipp Rathert
author_sort Philipp Rathert
title Structure, Activity and Function of the NSD3 Protein Lysine Methyltransferase
title_short Structure, Activity and Function of the NSD3 Protein Lysine Methyltransferase
title_full Structure, Activity and Function of the NSD3 Protein Lysine Methyltransferase
title_fullStr Structure, Activity and Function of the NSD3 Protein Lysine Methyltransferase
title_full_unstemmed Structure, Activity and Function of the NSD3 Protein Lysine Methyltransferase
title_sort structure, activity and function of the nsd3 protein lysine methyltransferase
publisher MDPI AG
series Life
issn 2075-1729
publishDate 2021-07-01
description NSD3 is one of six H3K36-specific lysine methyltransferases in metazoans, and the methylation of H3K36 is associated with active transcription. NSD3 is a member of the nuclear receptor-binding SET domain (NSD) family of histone methyltransferases together with NSD1 and NSD2, which generate mono- and dimethylated lysine on histone H3. NSD3 is mutated and hyperactive in some human cancers, but the biochemical mechanisms underlying such dysregulation are barely understood. In this review, the current knowledge of NSD3 is systematically reviewed. Finally, the molecular and functional characteristics of NSD3 in different tumor types according to the current research are summarized.
topic NSD3
WHSC1L1
structure and function
url https://www.mdpi.com/2075-1729/11/8/726
work_keys_str_mv AT philipprathert structureactivityandfunctionofthensd3proteinlysinemethyltransferase
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