Chemotherapeutic Efficacy of Phosphodiesterase Inhibitors in Chagasic Cardiomyopathy

Chemotherapeutic Efficacy of Phosphodiesterase Inhibitors in Chagasic Cardiomyopathy

Molecular mechanisms of Trypanosoma cruzi (Tc)-induced Chagasic cardiomyopathy (CCM) are not well understood. The NO-cGMP-PKG1α pathway maintains cardiac homeostasis and inotropy and may be disturbed due to phosphodiesterase (PDE5)-mediated cGMP catabolism in CCM. To test this, C57BL/6 mice were inf...

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Bibliographic Details
Main Authors: Jian-jun Wen, PhD, Xianxiu Wan, MS, John Thacker, BS, Nisha Jain Garg, PhD
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:JACC: Basic to Translational Science
Subjects:
antioxidant/oxidant balance
chagasic cardiomyopathy
chronic inflammation
LV function
mitochondrial respiration
sildenafil
Trypanosoma cruzi
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X16300262

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http://www.sciencedirect.com/science/article/pii/S2452302X16300262

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