Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cells
Abstract Cystic fibrosis (CF) is a genetic disease characterized by CF transmembrane regulator (CFTR) dysfunction. With over 2000 CFTR variants identified, in addition to known patient to patient variability, there is a need for personalized treatment. The discovery of CFTR modulators has shown effi...
Main Authors: | Jenny P. Nguyen, Matthew Bianca, Ryan D. Huff, Nicholas Tiessen, Mark D. Inman, Jeremy A. Hirota |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-01-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-79555-w |
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