Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population.

Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population.

BACKGROUND:Chronic inflammation is involved in the pathogenesis of chronic age-associated, degenerative diseases. Pro-inflammatory host responses that are deleterious later in life may originate from evolutionary selection for genetic variation mediating resistance to infectious diseases under adver...

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Main Authors: Maris Kuningas, Linda May, Riin Tamm, David van Bodegom, Anita H J van den Biggelaar, Johannes J Meij, Marijke Frölich, Juventus B Ziem, Helena E D Suchiman, Andres Metspalu, P Eline Slagboom, Rudi G J Westendorp
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2771352?pdf=render

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