Expression Status and Prognostic Value of m⁶A RNA Methylation Regulators in Lung Adenocarcinoma

• Main Authors: Xiuhong Li, Zian Feng, Rui Wang, Jie Hu, Xiaodong He, Zuojun Shen
• Format: Article
• Language: English
• Published: MDPI AG 2021-06-01
• Series: Life
• Subjects: m⁶A methylation; lung adenocarcinoma; prognostic signature; survival analysis
• Online Access: https://www.mdpi.com/2075-1729/11/7/619

N⁶-methyladenosine (m⁶A) RNA modification is the most abundant modification method in mRNA, and it plays an important role in the occurrence and development of many cancers. This paper mainly discusses the role of m⁶A RNA methylation regulators in lung adenocarcinoma (LUAD) to identify novel prognostic biomarkers. The gene expression data of 19 m⁶A methylation regulators in LUAD patients and its relevant clinical parameters were extracted from The Cancer Genome Atlas (TCGA) database. We selected three significantly differentially expressed m⁶A regulators in LUAD to construct the risk signature, and evaluated its prognostic prediction efficiency using the receiver operating characteristic (ROC) curve. Kaplan–Meier survival analysis and Cox regression analysis were used to identify the independent prognostic significance of the risk signature. The ROC curve indicated that the area under the curve (AUC) was 0.659, which means that the risk signature had a good prediction efficiency. The results of the Kaplan–Meier survival analysis and Cox regression analysis showed that the risk score can be used as an independent prognostic factor for LUAD. In addition, we explored the differential signaling pathways and cellular processes related to m⁶A methylation regulators in LUAD.