Vitamin D and Its Role in the Lipid Metabolism and the Development of Atherosclerosis

• Main Authors: Andrei Mihai Surdu, Oana Pînzariu, Dana-Mihaela Ciobanu, Alina-Gabriela Negru, Simona-Sorana Căinap, Cecilia Lazea, Daniela Iacob, George Săraci, Dacian Tirinescu, Ileana Monica Borda, Gabriel Cismaru
• Format: Article
• Language: English
• Published: MDPI AG 2021-02-01
• Series: Biomedicines
• Subjects: vitamin D; cardiovascular; atherosclerosis; 25-OH vitamin D; rickets; osteomalacia
• Online Access: https://www.mdpi.com/2227-9059/9/2/172

Vitamin D, a crucial hormone in the homeostasis and metabolism of calcium bone, has lately been found to produce effects on other physiological and pathological processes genomically and non-genomically, including the cardiovascular system. While lower baseline vitamin D levels have been correlated with atherogenic blood lipid profiles, 25(OH)D supplementation influences the levels of serum lipids in that it lowers the levels of total cholesterol, triglycerides, and LDL-cholesterol and increases the levels of HDL-cholesterol, all of which are known risk factors for cardiovascular disease. Vitamin D is also involved in the development of atherosclerosis at the site of the blood vessels. Deficiency of this vitamin has been found to increase adhesion molecules or endothelial activation and, at the same time, supplementation is linked to the lowering presence of adhesion surrogates. Vitamin D can also influence the vascular tone by increasing endothelial nitric oxide production, as seen in supplementation studies. Deficiency can lead, at the same time, to oxidative stress and an increase in inflammation as well as the expression of particular immune cells that play a pivotal role in the development of atherosclerosis in the intima of the blood vessels, i.e., monocytes and macrophages. Vitamin D is also involved in atherogenesis through inhibition of vascular smooth muscle cell proliferation. Furthermore, vitamin D deficiency is consistently associated with cardiovascular events, such as myocardial infarction, STEMI, NSTEMI, unstable angina, ischemic stroke, cardiovascular death, and increased mortality after acute stroke. Conversely, vitamin D supplementation does not seem to produce beneficial effects in cohorts with intermediate baseline vitamin D levels.