Very short cycles of postconditioning have no protective effect against reperfusion injury. Experimental study in rats
Introduction: Ischemic postconditioning has been recognized as effective in the prevention of reperfusion injury in situations of ischemia and reperfusion in various organs and tissues. However, it remains unclear what would be the best way to accomplish it, since studies show great variation in the...
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Sociedade Brasileira de Cirurgia Cardiovascular
2014-12-01
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doaj-c45ff93c66084b7897a2c46f25862ce32020-11-25T01:24:57ZengSociedade Brasileira de Cirurgia CardiovascularBrazilian Journal of Cardiovascular Surgery1678-97412014-12-0129452152610.5935/1678-9741.20140088S0102-76382014000400008Very short cycles of postconditioning have no protective effect against reperfusion injury. Experimental study in ratsRicardo Kenithi NakamuraCarlos Henrique Marques dos SantosLuciana Nakao Odashiro MiijiMariana Sousa ArakakiCristiane Midori MaedoMaurício Érnica FilhoPedro Carvalho CassinoElenir Rose Jardim Cury PontesIntroduction: Ischemic postconditioning has been recognized as effective in the prevention of reperfusion injury in situations of ischemia and reperfusion in various organs and tissues. However, it remains unclear what would be the best way to accomplish it, since studies show great variation in the method of their application. Objective: To assess the protective effect of ischemic postconditioning on ischemia and reperfusion in rats undergoing five alternating cycles of reperfusion and ischemia of 30 seconds each one. Methods: We studied 25 Wistar rats distributed in three groups: group A (10 rats), which underwent mesenteric ischemia (30 minutes) and reperfusion (60 minutes); Group B (10 rats), undergoing ischemia (30 minutes) and reperfusion (60 minutes), intercalated by postconditioning (5 alternating cycles of reperfusion and ischemia of 30 seconds each one); and group C - SHAM (5 rats), undergoing only laparotomy and manipulation of mesenteric artery. All animals underwent resection of an ileum segment for histological analysis. Results: The mean lesions degree according to Chiu et al. were: group A, 2.77, group B, 2.67 and group C, 0.12. There was no difference between groups A and B (P>0.05). Conclusion: Ischemic postconditioning was not able to minimize or prevent the intestinal tissue injury in rats undergoing ischemia and reperfusion process when used five cycles lasting 30 seconds each one.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382014000400008&lng=en&tlng=enPós-Condicionamento IsquêmicoIsquemiaReperfusãoOclusão Vascular MesentéricaRatos |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ricardo Kenithi Nakamura Carlos Henrique Marques dos Santos Luciana Nakao Odashiro Miiji Mariana Sousa Arakaki Cristiane Midori Maedo Maurício Érnica Filho Pedro Carvalho Cassino Elenir Rose Jardim Cury Pontes |
spellingShingle |
Ricardo Kenithi Nakamura Carlos Henrique Marques dos Santos Luciana Nakao Odashiro Miiji Mariana Sousa Arakaki Cristiane Midori Maedo Maurício Érnica Filho Pedro Carvalho Cassino Elenir Rose Jardim Cury Pontes Very short cycles of postconditioning have no protective effect against reperfusion injury. Experimental study in rats Brazilian Journal of Cardiovascular Surgery Pós-Condicionamento Isquêmico Isquemia Reperfusão Oclusão Vascular Mesentérica Ratos |
author_facet |
Ricardo Kenithi Nakamura Carlos Henrique Marques dos Santos Luciana Nakao Odashiro Miiji Mariana Sousa Arakaki Cristiane Midori Maedo Maurício Érnica Filho Pedro Carvalho Cassino Elenir Rose Jardim Cury Pontes |
author_sort |
Ricardo Kenithi Nakamura |
title |
Very short cycles of postconditioning have no protective effect against reperfusion injury. Experimental study in rats |
title_short |
Very short cycles of postconditioning have no protective effect against reperfusion injury. Experimental study in rats |
title_full |
Very short cycles of postconditioning have no protective effect against reperfusion injury. Experimental study in rats |
title_fullStr |
Very short cycles of postconditioning have no protective effect against reperfusion injury. Experimental study in rats |
title_full_unstemmed |
Very short cycles of postconditioning have no protective effect against reperfusion injury. Experimental study in rats |
title_sort |
very short cycles of postconditioning have no protective effect against reperfusion injury. experimental study in rats |
publisher |
Sociedade Brasileira de Cirurgia Cardiovascular |
series |
Brazilian Journal of Cardiovascular Surgery |
issn |
1678-9741 |
publishDate |
2014-12-01 |
description |
Introduction: Ischemic postconditioning has been recognized as effective in the prevention of reperfusion injury in situations of ischemia and reperfusion in various organs and tissues. However, it remains unclear what would be the best way to accomplish it, since studies show great variation in the method of their application. Objective: To assess the protective effect of ischemic postconditioning on ischemia and reperfusion in rats undergoing five alternating cycles of reperfusion and ischemia of 30 seconds each one. Methods: We studied 25 Wistar rats distributed in three groups: group A (10 rats), which underwent mesenteric ischemia (30 minutes) and reperfusion (60 minutes); Group B (10 rats), undergoing ischemia (30 minutes) and reperfusion (60 minutes), intercalated by postconditioning (5 alternating cycles of reperfusion and ischemia of 30 seconds each one); and group C - SHAM (5 rats), undergoing only laparotomy and manipulation of mesenteric artery. All animals underwent resection of an ileum segment for histological analysis. Results: The mean lesions degree according to Chiu et al. were: group A, 2.77, group B, 2.67 and group C, 0.12. There was no difference between groups A and B (P>0.05). Conclusion: Ischemic postconditioning was not able to minimize or prevent the intestinal tissue injury in rats undergoing ischemia and reperfusion process when used five cycles lasting 30 seconds each one. |
topic |
Pós-Condicionamento Isquêmico Isquemia Reperfusão Oclusão Vascular Mesentérica Ratos |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382014000400008&lng=en&tlng=en |
work_keys_str_mv |
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