Insight into Conformational Change for 14-3-3σ Protein by Molecular Dynamics Simulation

Insight into Conformational Change for 14-3-3σ Protein by Molecular Dynamics Simulation

14-3-3σ is a member of a highly conserved family of 14-3-3 proteins that has a double-edged sword role in human cancers. Former reports have indicated that the 14-3-3 protein may be in an open or closed state. In this work, we found that the apo-14-3-3σ is in an open state compared with the phosphop...

Full description

Bibliographic Details
Main Authors: Guodong Hu, Haiyan Li, Jing-Yuan Liu, Jihua Wang
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:International Journal of Molecular Sciences
Subjects:
conformational change
14-3-3σ protein
molecular dynamics simulation
Online Access:http://www.mdpi.com/1422-0067/15/2/2794

Similar Items

Similar Items