The Relationship Between Vitamin B6, Diabetes and Cancer
Pyridoxal 5′-phosphate (PLP), the active form of vitamin B6, works as cofactor in numerous enzymatic reactions and it behaves as antioxidant molecule. PLP deficiency has been associated to many human pathologies including cancer and diabetes and the mechanism behind this connection is now becoming c...
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doaj-c477b98d6169496eb87e9d846d91a14a2020-11-24T20:58:33ZengFrontiers Media S.A.Frontiers in Genetics1664-80212018-09-01910.3389/fgene.2018.00388413618The Relationship Between Vitamin B6, Diabetes and CancerChiara Merigliano0Elisa Mascolo1Romina Burla2Isabella Saggio3Isabella Saggio4Fiammetta Vernì5Dipartimento di Biologia e Biotecnologie “C. Darwin," Sapienza Università di Roma, Rome, ItalyDipartimento di Biologia e Biotecnologie “C. Darwin," Sapienza Università di Roma, Rome, ItalyDipartimento di Biologia e Biotecnologie “C. Darwin," Sapienza Università di Roma, Rome, ItalyDipartimento di Biologia e Biotecnologie “C. Darwin," Sapienza Università di Roma, Rome, ItalyInstitute of Structural Biology, School of Biological Sciences, Nanyang Technological University, Singapore, SingaporeDipartimento di Biologia e Biotecnologie “C. Darwin," Sapienza Università di Roma, Rome, ItalyPyridoxal 5′-phosphate (PLP), the active form of vitamin B6, works as cofactor in numerous enzymatic reactions and it behaves as antioxidant molecule. PLP deficiency has been associated to many human pathologies including cancer and diabetes and the mechanism behind this connection is now becoming clearer. Inadequate intake of this vitamin increases the risk of many cancers; furthermore, PLP deprivation impairs insulin secretion in rats, whereas PLP supplementation prevents diabetic complications and improves gestational diabetes. Growing evidence shows that diabetes and cancer are correlated not only because they share same risk factors but also because diabetic patients have a higher risk of developing tumors, although the underlying mechanisms remain elusive. In this review, we will explore data obtained in Drosophila revealing the existence of a connection between vitamin B6, DNA damage and diabetes, as flies in the past decade turned out to be a promising model also for metabolic diseases including diabetes. We will focus on recent studies that revealed a specific role for PLP in maintaining chromosome integrity and glucose homeostasis, and we will show that these aspects are correlated. In addition, we will discuss recent data identifying PLP as a putative linking factor between diabetes and cancer.https://www.frontiersin.org/article/10.3389/fgene.2018.00388/fullvitamin B6pyridoxal 5′- phosphatediabeteschromosome aberrationsDrosophilaAGEs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chiara Merigliano Elisa Mascolo Romina Burla Isabella Saggio Isabella Saggio Fiammetta Vernì |
spellingShingle |
Chiara Merigliano Elisa Mascolo Romina Burla Isabella Saggio Isabella Saggio Fiammetta Vernì The Relationship Between Vitamin B6, Diabetes and Cancer Frontiers in Genetics vitamin B6 pyridoxal 5′- phosphate diabetes chromosome aberrations Drosophila AGEs |
author_facet |
Chiara Merigliano Elisa Mascolo Romina Burla Isabella Saggio Isabella Saggio Fiammetta Vernì |
author_sort |
Chiara Merigliano |
title |
The Relationship Between Vitamin B6, Diabetes and Cancer |
title_short |
The Relationship Between Vitamin B6, Diabetes and Cancer |
title_full |
The Relationship Between Vitamin B6, Diabetes and Cancer |
title_fullStr |
The Relationship Between Vitamin B6, Diabetes and Cancer |
title_full_unstemmed |
The Relationship Between Vitamin B6, Diabetes and Cancer |
title_sort |
relationship between vitamin b6, diabetes and cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2018-09-01 |
description |
Pyridoxal 5′-phosphate (PLP), the active form of vitamin B6, works as cofactor in numerous enzymatic reactions and it behaves as antioxidant molecule. PLP deficiency has been associated to many human pathologies including cancer and diabetes and the mechanism behind this connection is now becoming clearer. Inadequate intake of this vitamin increases the risk of many cancers; furthermore, PLP deprivation impairs insulin secretion in rats, whereas PLP supplementation prevents diabetic complications and improves gestational diabetes. Growing evidence shows that diabetes and cancer are correlated not only because they share same risk factors but also because diabetic patients have a higher risk of developing tumors, although the underlying mechanisms remain elusive. In this review, we will explore data obtained in Drosophila revealing the existence of a connection between vitamin B6, DNA damage and diabetes, as flies in the past decade turned out to be a promising model also for metabolic diseases including diabetes. We will focus on recent studies that revealed a specific role for PLP in maintaining chromosome integrity and glucose homeostasis, and we will show that these aspects are correlated. In addition, we will discuss recent data identifying PLP as a putative linking factor between diabetes and cancer. |
topic |
vitamin B6 pyridoxal 5′- phosphate diabetes chromosome aberrations Drosophila AGEs |
url |
https://www.frontiersin.org/article/10.3389/fgene.2018.00388/full |
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