IL-1α -889 C/T polymorphism and cancer susceptibility: a meta-analysis
Daye Cheng, Yiwen Hao, Wenling Zhou Department of Transfusion, First Hospital of China Medical University, Shenyang, People's Republic of China Abstract: The -889 C/T polymorphism in the interleukin-1α (IL-1α) gene has been implicated in the risk of cancer, but the resu...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Dove Medical Press
2014-11-01
|
Series: | OncoTargets and Therapy |
Online Access: | http://www.dovepress.com/il-1alpha--889-ct-polymorphism-and-cancer-susceptibility-a-meta-analys-peer-reviewed-article-OTT |
id |
doaj-c483fb01c4e94a3eb214da4a3c7405a4 |
---|---|
record_format |
Article |
spelling |
doaj-c483fb01c4e94a3eb214da4a3c7405a42020-11-24T23:08:53ZengDove Medical PressOncoTargets and Therapy1178-69302014-11-012014default2067207419088IL-1α -889 C/T polymorphism and cancer susceptibility: a meta-analysisCheng DHao YZhou W Daye Cheng, Yiwen Hao, Wenling Zhou Department of Transfusion, First Hospital of China Medical University, Shenyang, People's Republic of China Abstract: The -889 C/T polymorphism in the interleukin-1α (IL-1α) gene has been implicated in the risk of cancer, but the results are inconclusive. The present meta-analysis aimed to investigate the association between the -889 C/T polymorphism and cancer risk. A literature search in PubMed, Embase™, Web of Science™, Science Direct®, SpringerLink, EBSCO, Wanfang, and Chinese National Knowledge Infrastructure (CNKI) databases was carried out to identify studies investigating the association between IL-1α -889 C/T polymorphism and cancer risk. The odds ratio (OR) with 95% confidence interval (CI) were used to assess the strength of association. A total of 20 publications, involving 6,782 cases and 7,767 controls, were included in this meta-analysis. Combined analysis revealed a significant association between -889 C/T polymorphism and cancer risk under an allele model (OR =1.12, 95% CI =1.02–1.24, P=0.02), recessive model (OR =1.34, 95% CI =1.06–1.68, P=0.01), and homozygous comparison (OR =1.38, 95% CI =1.10–1.74, P<0.01). Subgroup analysis by ethnicity showed there was significant association between cancer risk and IL-1a -889C/T polymorphism in Asian populations under a recessive model (OR =2.57, 95% CI =1.11–5.98, P=0.03) and homozygous comparison (OR =2.60, 95% CI =1.12–6.04, P=0.03). Moreover, a subgroup analysis was conducted by source of control, and a statistically increased cancer risk was found in the hospital-based group, under a recessive model (OR =1.62, 95% CI =1.03–2.56, P=0.04) and homozygous comparison (OR =1.67, 95% CI =1.04–2.68, P=0.03). This meta-analysis suggests that IL-1α -889 C/T polymorphism contributes to cancer susceptibility. Further large and well-designed studies are needed to confirm this association. Keywords: neoplasma, biomarker, cytokine, systematic reviewhttp://www.dovepress.com/il-1alpha--889-ct-polymorphism-and-cancer-susceptibility-a-meta-analys-peer-reviewed-article-OTT |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cheng D Hao Y Zhou W |
spellingShingle |
Cheng D Hao Y Zhou W IL-1α -889 C/T polymorphism and cancer susceptibility: a meta-analysis OncoTargets and Therapy |
author_facet |
Cheng D Hao Y Zhou W |
author_sort |
Cheng D |
title |
IL-1α -889 C/T polymorphism and cancer susceptibility: a meta-analysis |
title_short |
IL-1α -889 C/T polymorphism and cancer susceptibility: a meta-analysis |
title_full |
IL-1α -889 C/T polymorphism and cancer susceptibility: a meta-analysis |
title_fullStr |
IL-1α -889 C/T polymorphism and cancer susceptibility: a meta-analysis |
title_full_unstemmed |
IL-1α -889 C/T polymorphism and cancer susceptibility: a meta-analysis |
title_sort |
il-1α -889 c/t polymorphism and cancer susceptibility: a meta-analysis |
publisher |
Dove Medical Press |
series |
OncoTargets and Therapy |
issn |
1178-6930 |
publishDate |
2014-11-01 |
description |
Daye Cheng, Yiwen Hao, Wenling Zhou Department of Transfusion, First Hospital of China Medical University, Shenyang, People's Republic of China Abstract: The -889 C/T polymorphism in the interleukin-1α (IL-1α) gene has been implicated in the risk of cancer, but the results are inconclusive. The present meta-analysis aimed to investigate the association between the -889 C/T polymorphism and cancer risk. A literature search in PubMed, Embase™, Web of Science™, Science Direct®, SpringerLink, EBSCO, Wanfang, and Chinese National Knowledge Infrastructure (CNKI) databases was carried out to identify studies investigating the association between IL-1α -889 C/T polymorphism and cancer risk. The odds ratio (OR) with 95% confidence interval (CI) were used to assess the strength of association. A total of 20 publications, involving 6,782 cases and 7,767 controls, were included in this meta-analysis. Combined analysis revealed a significant association between -889 C/T polymorphism and cancer risk under an allele model (OR =1.12, 95% CI =1.02–1.24, P=0.02), recessive model (OR =1.34, 95% CI =1.06–1.68, P=0.01), and homozygous comparison (OR =1.38, 95% CI =1.10–1.74, P<0.01). Subgroup analysis by ethnicity showed there was significant association between cancer risk and IL-1a -889C/T polymorphism in Asian populations under a recessive model (OR =2.57, 95% CI =1.11–5.98, P=0.03) and homozygous comparison (OR =2.60, 95% CI =1.12–6.04, P=0.03). Moreover, a subgroup analysis was conducted by source of control, and a statistically increased cancer risk was found in the hospital-based group, under a recessive model (OR =1.62, 95% CI =1.03–2.56, P=0.04) and homozygous comparison (OR =1.67, 95% CI =1.04–2.68, P=0.03). This meta-analysis suggests that IL-1α -889 C/T polymorphism contributes to cancer susceptibility. Further large and well-designed studies are needed to confirm this association. Keywords: neoplasma, biomarker, cytokine, systematic review |
url |
http://www.dovepress.com/il-1alpha--889-ct-polymorphism-and-cancer-susceptibility-a-meta-analys-peer-reviewed-article-OTT |
work_keys_str_mv |
AT chengd il1alpha889ctpolymorphismandcancersusceptibilityametaanalysis AT haoy il1alpha889ctpolymorphismandcancersusceptibilityametaanalysis AT zhouw il1alpha889ctpolymorphismandcancersusceptibilityametaanalysis |
_version_ |
1725612563810484224 |