The Effects of Autophagy and PI3K/AKT/m-TOR Signaling Pathway on the Cell-Cycle Arrest of Rats Primary Sertoli Cells Induced by Zearalenone

The Effects of Autophagy and PI3K/AKT/m-TOR Signaling Pathway on the Cell-Cycle Arrest of Rats Primary Sertoli Cells Induced by Zearalenone

A high concentration of Zearalenone (ZEA) will perturb the differentiation of germ cells, and induce a death of germ cells, but the toxic mechanism and molecular mechanism remain unclear. The Sertoli cells (SCs) play an irreplaceable role in spermatogenesis. In order to explore the potential mechani...

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Bibliographic Details
Main Authors: Bing-jie Wang, Wang-long Zheng, Nan-nan Feng, Tao Wang, Hui Zou, Jian-hong Gu, Yan Yuan, Xue-zhong Liu, Zong-ping Liu, Jian-chun Bian
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Toxins
Subjects:
Zearalenone (ZEA)
Sertoli cells (SCs)
cell cycle
G2/M arrest
Autophagy
PI3K/Akt/m TOR signaling
Online Access:http://www.mdpi.com/2072-6651/10/10/398

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