INDAPAMIDE POTENTIAL AT VARIOUS STAGES OF CARDIOVASCULAR CONTINUUM AND IN SPECIFIC CLINICAL GROUPS
Starting from the 1960s, thiazide diuretics have been widely used for arterial hypertension management. In prospective studies, their role in reducing the risk of cardiovascular events was demonstrated. A thiazide-like diuretic indapamide is used in low doses, and, in contrast to thiazide diuretics,...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2010-12-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1522 |
| Summary: | Starting from the 1960s, thiazide diuretics have been widely used for arterial hypertension management. In prospective studies, their role in reducing the risk of cardiovascular events was demonstrated. A thiazide-like diuretic indapamide is used in low doses, and, in contrast to thiazide diuretics, affects NaCl reabsorption to a lesser extent; therefore, it is linked to minimal Ka excretion. Indapamide acts as a peripheral vasodilator due to calcium channel blockade and increased synthesis of PgE2 . Several Russian studies demonstrated that Indap has good antihypertensive, cardio- and nephroprotective effectiveness, and is metabolically neutral. In a comparative trial, Indap was biologically and therapeutically equivalent to both forms of the original medication. This agent could be used as monotherapy, or in combination with medications of other classes. |
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| ISSN: | 1560-4071 2618-7620 |