INDAPAMIDE POTENTIAL AT VARIOUS STAGES OF CARDIOVASCULAR CONTINUUM AND IN SPECIFIC CLINICAL GROUPS

• Main Author: M. N. Mamedov
• Format: Article
• Language: Russian
• Published: «FIRMA «SILICEA» LLC 2010-12-01
• Series: Российский кардиологический журнал
• Subjects: arterial hypertension; indapamide; effectiveness; mechanism of action
• Online Access: https://russjcardiol.elpub.ru/jour/article/view/1522

Starting from the 1960s, thiazide diuretics have been widely used for arterial hypertension management. In prospective studies, their role in reducing the risk of cardiovascular events was demonstrated. A thiazide-like diuretic indapamide is used in low doses, and, in contrast to thiazide diuretics, affects NaCl reabsorption to a lesser extent; therefore, it is linked to minimal Ka excretion. Indapamide acts as a peripheral vasodilator due to calcium channel blockade and increased synthesis of PgE2 . Several Russian studies demonstrated that Indap has good antihypertensive, cardio- and nephroprotective effectiveness, and is metabolically neutral. In a comparative trial, Indap was biologically and therapeutically equivalent to both forms of the original medication. This agent could be used as monotherapy, or in combination with medications of other classes.