Evaluation of the association between quantitative mammographic density and breast cancer occurred in different quadrants
Abstract Background To investigate the relationship between mammographic density measured in four quadrants of a breast with the location of the occurred cancer. Methods One hundred and ten women diagnosed with unilateral breast cancer that could be determined in one specific breast quadrant were re...
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doaj-c4a1ac8dd262485892a293d5462ef53c2020-11-24T21:56:33ZengBMCBMC Cancer1471-24072017-04-0117111110.1186/s12885-017-3270-0Evaluation of the association between quantitative mammographic density and breast cancer occurred in different quadrantsSiwa Chan0Jeon-Hor Chen1Shunshan Li2Rita Chang3Darh-Cherng Yeh4Ruey-Feng Chang5Lee-Ren Yeh6Jessica Kwong7Min-Ying Su8Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan UniversityCenter for Functional Onco-Imaging, Department of Radiological Sciences, University of CaliforniaCenter for Functional Onco-Imaging, Department of Radiological Sciences, University of CaliforniaCenter for Functional Onco-Imaging, Department of Radiological Sciences, University of CaliforniaBreast Cancer Center, Tzu Chi General HospitalGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan UniversityDepartment of Radiology, E-Da Hospital and I-Shou UniversityCenter for Functional Onco-Imaging, Department of Radiological Sciences, University of CaliforniaCenter for Functional Onco-Imaging, Department of Radiological Sciences, University of CaliforniaAbstract Background To investigate the relationship between mammographic density measured in four quadrants of a breast with the location of the occurred cancer. Methods One hundred and ten women diagnosed with unilateral breast cancer that could be determined in one specific breast quadrant were retrospectively studied. Women with previous cancer/breast surgery were excluded. The craniocaudal (CC) and mediolateral oblique (MLO) mammography of the contralateral normal breast were used to separate a breast into 4 quadrants: Upper-Outer (UO), Upper-Inner (UI), Lower-Outer (LO), and Lower-Inner (LI). The breast area (BA), dense area (DA), and percent density (PD) in each quadrant were measured by using the fuzzy-C-means segmentation. The BA, DA, and PD were compared between patients who had cancer occurring in different quadrants. Results The upper-outer quadrant had the highest BA (37 ± 15 cm2) and DA (7.1 ± 2.9 cm2), with PD = 20.0 ± 5.8%. The order of BA and DA in the 4 separated quadrants were: UO > UI > LO > LI, and almost all pair-wise comparisons showed significant differences. For tumor location, 67 women (60.9%) had tumor in UO, 16 (14.5%) in UI, 7 (6.4%) in LO, and 20 (18.2%) in LI quadrant, respectively. The estimated odds and the 95% confidence limits of tumor development in the UO, UI, LO and LI quadrants were 1.56 (1.06, 2.29), 0.17 (0.10, 0.29), 0.07 (0.03, 0.15), and 0.22 (0.14, 0.36), respectively. In these 4 groups of women, the order of quadrant BA and DA were all the same (UO > UI > LO > LI), and there was no significant difference in BA, DA or PD among them (all p > 0.05). Conclusions Breast cancer was most likely to occur in the UO quadrant, which was also the quadrant with highest BA and DA; but for women with tumors in other quadrants, the density in that quadrant was not the highest. Therefore, there was no direct association between quadrant density and tumor occurrence.http://link.springer.com/article/10.1186/s12885-017-3270-0Mammographic densityBreast cancerBreast quadrantDense areaPercent densityUpper-outer quadrant |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Siwa Chan Jeon-Hor Chen Shunshan Li Rita Chang Darh-Cherng Yeh Ruey-Feng Chang Lee-Ren Yeh Jessica Kwong Min-Ying Su |
spellingShingle |
Siwa Chan Jeon-Hor Chen Shunshan Li Rita Chang Darh-Cherng Yeh Ruey-Feng Chang Lee-Ren Yeh Jessica Kwong Min-Ying Su Evaluation of the association between quantitative mammographic density and breast cancer occurred in different quadrants BMC Cancer Mammographic density Breast cancer Breast quadrant Dense area Percent density Upper-outer quadrant |
author_facet |
Siwa Chan Jeon-Hor Chen Shunshan Li Rita Chang Darh-Cherng Yeh Ruey-Feng Chang Lee-Ren Yeh Jessica Kwong Min-Ying Su |
author_sort |
Siwa Chan |
title |
Evaluation of the association between quantitative mammographic density and breast cancer occurred in different quadrants |
title_short |
Evaluation of the association between quantitative mammographic density and breast cancer occurred in different quadrants |
title_full |
Evaluation of the association between quantitative mammographic density and breast cancer occurred in different quadrants |
title_fullStr |
Evaluation of the association between quantitative mammographic density and breast cancer occurred in different quadrants |
title_full_unstemmed |
Evaluation of the association between quantitative mammographic density and breast cancer occurred in different quadrants |
title_sort |
evaluation of the association between quantitative mammographic density and breast cancer occurred in different quadrants |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2017-04-01 |
description |
Abstract Background To investigate the relationship between mammographic density measured in four quadrants of a breast with the location of the occurred cancer. Methods One hundred and ten women diagnosed with unilateral breast cancer that could be determined in one specific breast quadrant were retrospectively studied. Women with previous cancer/breast surgery were excluded. The craniocaudal (CC) and mediolateral oblique (MLO) mammography of the contralateral normal breast were used to separate a breast into 4 quadrants: Upper-Outer (UO), Upper-Inner (UI), Lower-Outer (LO), and Lower-Inner (LI). The breast area (BA), dense area (DA), and percent density (PD) in each quadrant were measured by using the fuzzy-C-means segmentation. The BA, DA, and PD were compared between patients who had cancer occurring in different quadrants. Results The upper-outer quadrant had the highest BA (37 ± 15 cm2) and DA (7.1 ± 2.9 cm2), with PD = 20.0 ± 5.8%. The order of BA and DA in the 4 separated quadrants were: UO > UI > LO > LI, and almost all pair-wise comparisons showed significant differences. For tumor location, 67 women (60.9%) had tumor in UO, 16 (14.5%) in UI, 7 (6.4%) in LO, and 20 (18.2%) in LI quadrant, respectively. The estimated odds and the 95% confidence limits of tumor development in the UO, UI, LO and LI quadrants were 1.56 (1.06, 2.29), 0.17 (0.10, 0.29), 0.07 (0.03, 0.15), and 0.22 (0.14, 0.36), respectively. In these 4 groups of women, the order of quadrant BA and DA were all the same (UO > UI > LO > LI), and there was no significant difference in BA, DA or PD among them (all p > 0.05). Conclusions Breast cancer was most likely to occur in the UO quadrant, which was also the quadrant with highest BA and DA; but for women with tumors in other quadrants, the density in that quadrant was not the highest. Therefore, there was no direct association between quadrant density and tumor occurrence. |
topic |
Mammographic density Breast cancer Breast quadrant Dense area Percent density Upper-outer quadrant |
url |
http://link.springer.com/article/10.1186/s12885-017-3270-0 |
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