Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways

Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways

Voltage-gated sodium channels (Na<sub>V</sub>s) are a key determinant of neuronal signalling. Neurotoxins from diverse taxa that selectively activate or inhibit Na<sub>V</sub> channels have helped unravel the role of Na<sub>V</sub> channels in diseases, including...

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Bibliographic Details
Main Authors: Yashad Dongol, Fernanda C. Cardoso, Richard J. Lewis
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Toxins
Subjects:
chronic pain
ick peptide
knottins
na<sub>v</sub>
spider venom
voltage-gated sodium channel
Online Access:https://www.mdpi.com/2072-6651/11/11/626

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