Strong Correlation of Renal Function with Choroidal Thickness in Patients with Type 2 Diabetes: Retrospective Cross-Sectional Study
The purpose of this study was to analyze the correlation between renal function and subfoveal choroidal thickness (SFChT) in treatment-naïve proliferative diabetic retinopathy (PDR) patients. This study included 85 eyes of 52 treatment-naïve PDR patients who underwent kidney function testing and uri...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-07-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/9/7/2171 |
id |
doaj-c4b2329c7bdb4f64a695333e22f9bd3e |
---|---|
record_format |
Article |
spelling |
doaj-c4b2329c7bdb4f64a695333e22f9bd3e2020-11-25T02:58:03ZengMDPI AGJournal of Clinical Medicine2077-03832020-07-0192171217110.3390/jcm9072171Strong Correlation of Renal Function with Choroidal Thickness in Patients with Type 2 Diabetes: Retrospective Cross-Sectional StudyMin Gyu Choi0Jee Taek Kim1Department of Ophthalmology, College of Medicine, Chung-Ang University Hospital, Seoul 06973, KoreaDepartment of Ophthalmology, College of Medicine, Chung-Ang University Hospital, Seoul 06973, KoreaThe purpose of this study was to analyze the correlation between renal function and subfoveal choroidal thickness (SFChT) in treatment-naïve proliferative diabetic retinopathy (PDR) patients. This study included 85 eyes of 52 treatment-naïve PDR patients who underwent kidney function testing and urinalysis and 42 eyes of 33 age-matched controls. Treatment-naïve eyes with PDR were categorized into pachychoroid and leptochoroid groups based on the SFChT of the control group. Kidney function profiles were compared between pachychoroid and leptochoroid groups; the relationship between kidney function profile and SFChT was evaluated using regression analysis. Compared with the pachychoroid group, the leptochoroid group had significantly higher serum creatinine (<i>p</i> = 0.026), cystatin C (<i>p</i> = 0.004), and phosphorus (<i>p</i> < 0.001) levels and a lower estimated glomerular filtration rate (eGFR) (<i>p</i> < 0.001). Multivariate linear regression analyses showed that SFChT was positively correlated with eGFR (Cystatin C) (<i>p</i> = 0.007) and negatively correlated with serum phosphorus (<i>p</i> = 0.001). SFChT of patients with eGFR < 30 mL/min/1.73 m<sup>2</sup> and serum phosphorus level ≥4.0 mg/dL was less than that of patients with higher eGFR and lower serum phosphorus level. The choroidal thickness of treatment-naïve PDR patients is closely affected by renal function. Kidney function test should be considered if SFChT of patients with treatment-naïve PDR is reduced.https://www.mdpi.com/2077-0383/9/7/2171diabetes complicationsdiabetes mellitusdiabetic retinopathydiabetic nephropathieschoroidal thicknessoptical coherence tomography |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Min Gyu Choi Jee Taek Kim |
spellingShingle |
Min Gyu Choi Jee Taek Kim Strong Correlation of Renal Function with Choroidal Thickness in Patients with Type 2 Diabetes: Retrospective Cross-Sectional Study Journal of Clinical Medicine diabetes complications diabetes mellitus diabetic retinopathy diabetic nephropathies choroidal thickness optical coherence tomography |
author_facet |
Min Gyu Choi Jee Taek Kim |
author_sort |
Min Gyu Choi |
title |
Strong Correlation of Renal Function with Choroidal Thickness in Patients with Type 2 Diabetes: Retrospective Cross-Sectional Study |
title_short |
Strong Correlation of Renal Function with Choroidal Thickness in Patients with Type 2 Diabetes: Retrospective Cross-Sectional Study |
title_full |
Strong Correlation of Renal Function with Choroidal Thickness in Patients with Type 2 Diabetes: Retrospective Cross-Sectional Study |
title_fullStr |
Strong Correlation of Renal Function with Choroidal Thickness in Patients with Type 2 Diabetes: Retrospective Cross-Sectional Study |
title_full_unstemmed |
Strong Correlation of Renal Function with Choroidal Thickness in Patients with Type 2 Diabetes: Retrospective Cross-Sectional Study |
title_sort |
strong correlation of renal function with choroidal thickness in patients with type 2 diabetes: retrospective cross-sectional study |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-07-01 |
description |
The purpose of this study was to analyze the correlation between renal function and subfoveal choroidal thickness (SFChT) in treatment-naïve proliferative diabetic retinopathy (PDR) patients. This study included 85 eyes of 52 treatment-naïve PDR patients who underwent kidney function testing and urinalysis and 42 eyes of 33 age-matched controls. Treatment-naïve eyes with PDR were categorized into pachychoroid and leptochoroid groups based on the SFChT of the control group. Kidney function profiles were compared between pachychoroid and leptochoroid groups; the relationship between kidney function profile and SFChT was evaluated using regression analysis. Compared with the pachychoroid group, the leptochoroid group had significantly higher serum creatinine (<i>p</i> = 0.026), cystatin C (<i>p</i> = 0.004), and phosphorus (<i>p</i> < 0.001) levels and a lower estimated glomerular filtration rate (eGFR) (<i>p</i> < 0.001). Multivariate linear regression analyses showed that SFChT was positively correlated with eGFR (Cystatin C) (<i>p</i> = 0.007) and negatively correlated with serum phosphorus (<i>p</i> = 0.001). SFChT of patients with eGFR < 30 mL/min/1.73 m<sup>2</sup> and serum phosphorus level ≥4.0 mg/dL was less than that of patients with higher eGFR and lower serum phosphorus level. The choroidal thickness of treatment-naïve PDR patients is closely affected by renal function. Kidney function test should be considered if SFChT of patients with treatment-naïve PDR is reduced. |
topic |
diabetes complications diabetes mellitus diabetic retinopathy diabetic nephropathies choroidal thickness optical coherence tomography |
url |
https://www.mdpi.com/2077-0383/9/7/2171 |
work_keys_str_mv |
AT mingyuchoi strongcorrelationofrenalfunctionwithchoroidalthicknessinpatientswithtype2diabetesretrospectivecrosssectionalstudy AT jeetaekkim strongcorrelationofrenalfunctionwithchoroidalthicknessinpatientswithtype2diabetesretrospectivecrosssectionalstudy |
_version_ |
1724708887154655232 |