Isolated splenic high-grade serous carcinoma: A case report

Isolated splenic high-grade serous carcinoma: A case report

We present a unique case of high-grade serous carcinoma isolated to the spleen at the time of diagnosis, without any tumor present in the ovary, fallopian tubes, omentum or uterus, which was pathologically consistent with metastatic Mullerian carcinoma. Tumor sequencing with the MSK-IMPACT (Memorial...

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Bibliographic Details
Main Authors: Ralph Rogers, Sarah Ehmann, William P. Tew, Vance Broach
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Gynecologic Oncology Reports
Subjects:
High-grade serous carcinoma
Splenic Mullerian carcinoma
Pluripotent spleen cell
TP53 hotspot mutation
PALB2 mutation
ARID1 somatic mutation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352578921001223
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spelling doaj-c4c08810a3e84d4babbfae3d9651e1372021-09-25T05:08:34ZengElsevierGynecologic Oncology Reports2352-57892021-08-0137100818Isolated splenic high-grade serous carcinoma: A case reportRalph Rogers0Sarah Ehmann1William P. Tew2Vance Broach3Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Obstetrics and Gynecology, Mercer University Memorial Health Medical Center, Savannah, GA, USAGynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USAGynecologic Medical Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USAGynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Obstetrics & Gynecology, Weill Cornell Medical College, New York, NY, USA; Corresponding author at: Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.We present a unique case of high-grade serous carcinoma isolated to the spleen at the time of diagnosis, without any tumor present in the ovary, fallopian tubes, omentum or uterus, which was pathologically consistent with metastatic Mullerian carcinoma. Tumor sequencing with the MSK-IMPACT (Memorial Sloan Kettering–Integrated Mutation Profiling of Actionable Cancer Targets) multigene tumor panel test was performed, which revealed somatic mutations in PALB2 and in ARID1, as well as a TP53 hotspot mutation.http://www.sciencedirect.com/science/article/pii/S2352578921001223High-grade serous carcinomaSplenic Mullerian carcinomaPluripotent spleen cellTP53 hotspot mutationPALB2 mutationARID1 somatic mutation
collection DOAJ
language English
format Article
sources DOAJ
author Ralph Rogers
Sarah Ehmann
William P. Tew
Vance Broach
spellingShingle Ralph Rogers
Sarah Ehmann
William P. Tew
Vance Broach
Isolated splenic high-grade serous carcinoma: A case report
Gynecologic Oncology Reports
High-grade serous carcinoma
Splenic Mullerian carcinoma
Pluripotent spleen cell
TP53 hotspot mutation
PALB2 mutation
ARID1 somatic mutation
author_facet Ralph Rogers
Sarah Ehmann
William P. Tew
Vance Broach
author_sort Ralph Rogers
title Isolated splenic high-grade serous carcinoma: A case report
title_short Isolated splenic high-grade serous carcinoma: A case report
title_full Isolated splenic high-grade serous carcinoma: A case report
title_fullStr Isolated splenic high-grade serous carcinoma: A case report
title_full_unstemmed Isolated splenic high-grade serous carcinoma: A case report
title_sort isolated splenic high-grade serous carcinoma: a case report
publisher Elsevier
series Gynecologic Oncology Reports
issn 2352-5789
publishDate 2021-08-01
description We present a unique case of high-grade serous carcinoma isolated to the spleen at the time of diagnosis, without any tumor present in the ovary, fallopian tubes, omentum or uterus, which was pathologically consistent with metastatic Mullerian carcinoma. Tumor sequencing with the MSK-IMPACT (Memorial Sloan Kettering–Integrated Mutation Profiling of Actionable Cancer Targets) multigene tumor panel test was performed, which revealed somatic mutations in PALB2 and in ARID1, as well as a TP53 hotspot mutation.
topic High-grade serous carcinoma
Splenic Mullerian carcinoma
Pluripotent spleen cell
TP53 hotspot mutation
PALB2 mutation
ARID1 somatic mutation
url http://www.sciencedirect.com/science/article/pii/S2352578921001223
work_keys_str_mv AT ralphrogers isolatedsplenichighgradeserouscarcinomaacasereport
AT sarahehmann isolatedsplenichighgradeserouscarcinomaacasereport
AT williamptew isolatedsplenichighgradeserouscarcinomaacasereport
AT vancebroach isolatedsplenichighgradeserouscarcinomaacasereport
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