PENGARUH PEMBERIAN EKSTRAK METANOL-AIR DAUN Macaranga tanarius L. TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS YANG TERBEBANI GLUKOSA
Abstract: This research aim to find out the effect of M. tanarius leaf methanol-water extract (MTME) whether it can lowering blood glucose levels. This research was experimental study with one way-complete-random design using 25 male rats which divided into five groups. The rats in group I were give...
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Universitas Sanata Dharma
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doaj-c4c1e938b494413091e39b48546be6f02020-11-25T01:35:18ZengUniversitas Sanata DharmaJurnal Farmasi Sains dan Komunitas1693-56832527-71462013-05-0110110.24071/jpsc.1018883PENGARUH PEMBERIAN EKSTRAK METANOL-AIR DAUN Macaranga tanarius L. TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS YANG TERBEBANI GLUKOSAMartina Tri HandayaniPhebe HendraAbstract: This research aim to find out the effect of M. tanarius leaf methanol-water extract (MTME) whether it can lowering blood glucose levels. This research was experimental study with one way-complete-random design using 25 male rats which divided into five groups. The rats in group I were given CMC 1% (negative control). The group II rats were given 0.45 g/kg BW dose of Glibenclamide (positive control). In group III, IV and V, the rats were given 0.43; 1.28; 3.84 g/kg BW doses of MTME orally. The hypoglycemic effect of MTME was tested by using the Oral Glucose Tolerance Test (OGTT) method. The blood-glucose contents were measured at the 0, 15, 30, 60, 90, 180, and 240 after the OGTT and treatment. The AUC were statistically analyzed using one way ANOVA and Scheffe test with 95 % convidence level. The result show that MTME at dose 0.43; 1.28; and 3.84 g/kg BW was effective in improving oral glucose tolerance. Keywords : Blood glucose, Methanol-water extract, Macaranga tanariushttp://e-journal.usd.ac.id/index.php/JFSK/article/view/88 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Martina Tri Handayani Phebe Hendra |
spellingShingle |
Martina Tri Handayani Phebe Hendra PENGARUH PEMBERIAN EKSTRAK METANOL-AIR DAUN Macaranga tanarius L. TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS YANG TERBEBANI GLUKOSA Jurnal Farmasi Sains dan Komunitas |
author_facet |
Martina Tri Handayani Phebe Hendra |
author_sort |
Martina Tri Handayani |
title |
PENGARUH PEMBERIAN EKSTRAK METANOL-AIR DAUN Macaranga tanarius L. TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS YANG TERBEBANI GLUKOSA |
title_short |
PENGARUH PEMBERIAN EKSTRAK METANOL-AIR DAUN Macaranga tanarius L. TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS YANG TERBEBANI GLUKOSA |
title_full |
PENGARUH PEMBERIAN EKSTRAK METANOL-AIR DAUN Macaranga tanarius L. TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS YANG TERBEBANI GLUKOSA |
title_fullStr |
PENGARUH PEMBERIAN EKSTRAK METANOL-AIR DAUN Macaranga tanarius L. TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS YANG TERBEBANI GLUKOSA |
title_full_unstemmed |
PENGARUH PEMBERIAN EKSTRAK METANOL-AIR DAUN Macaranga tanarius L. TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS YANG TERBEBANI GLUKOSA |
title_sort |
pengaruh pemberian ekstrak metanol-air daun macaranga tanarius l. terhadap penurunan kadar glukosa darah pada tikus yang terbebani glukosa |
publisher |
Universitas Sanata Dharma |
series |
Jurnal Farmasi Sains dan Komunitas |
issn |
1693-5683 2527-7146 |
publishDate |
2013-05-01 |
description |
Abstract: This research aim to find out the effect of M. tanarius leaf methanol-water extract (MTME) whether it can lowering blood glucose levels. This research was experimental study with one way-complete-random design using 25 male rats which divided into five groups. The rats in group I were given CMC 1% (negative control). The group II rats were given 0.45 g/kg BW dose of Glibenclamide (positive control). In group III, IV and V, the rats were given 0.43; 1.28; 3.84 g/kg BW doses of MTME orally. The hypoglycemic effect of MTME was tested by using the Oral Glucose Tolerance Test (OGTT) method. The blood-glucose contents were measured at the 0, 15, 30, 60, 90, 180, and 240 after the OGTT and treatment. The AUC were statistically analyzed using one way ANOVA and Scheffe test with 95 % convidence level. The result show that MTME at dose 0.43; 1.28; and 3.84 g/kg BW was effective in improving oral glucose tolerance.
Keywords : Blood glucose, Methanol-water extract, Macaranga tanarius |
url |
http://e-journal.usd.ac.id/index.php/JFSK/article/view/88 |
work_keys_str_mv |
AT martinatrihandayani pengaruhpemberianekstrakmetanolairdaunmacarangatanariuslterhadappenurunankadarglukosadarahpadatikusyangterbebaniglukosa AT phebehendra pengaruhpemberianekstrakmetanolairdaunmacarangatanariuslterhadappenurunankadarglukosadarahpadatikusyangterbebaniglukosa |
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