Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins

• Main Authors: Alan R. Kimmel, Dawn L. Brasaemle, Monica McAndrews-Hill, Carole Sztalryd, Constantine Londos
• Format: Article
• Language: English
• Published: Elsevier 2010-03-01
• Series: Journal of Lipid Research
• Subjects: perilipin; adipocyte differentiation-related protein; adipophilin; tail-interacting protein of 47 kDa
• Online Access: http://www.sciencedirect.com/science/article/pii/S0022227520305046
• ISSN: 0022-2275

The PAT family of proteins has been identified in eukaryotic species as diverse as vertebrates, insects, and amebazoa. These proteins share a highly conserved sequence organization and avidity for the surfaces of intracellular, neutral lipid storage droplets. The current nomenclature of the various members lacks consistency and precision, deriving more from historic context than from recognition of evolutionary relationship and shared function. In consultation with the Mouse Genomic Nomenclature Committee, the Human Genome Organization Genomic Nomenclature Committee, and conferees at the 2007 FASEB Conference on Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lipids, we have established a unifying nomenclature for the gene and protein family members. Each gene member will incorporate the root term PERILIPIN (PLIN), the founding gene of the PAT family, with the different genes/proteins numbered sequentially.