Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins
The PAT family of proteins has been identified in eukaryotic species as diverse as vertebrates, insects, and amebazoa. These proteins share a highly conserved sequence organization and avidity for the surfaces of intracellular, neutral lipid storage droplets. The current nomenclature of the various...
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doaj-c4d2939ad8b84ccf938f6e377e3594ef2021-04-28T05:55:28ZengElsevierJournal of Lipid Research0022-22752010-03-01513468471Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteinsAlan R. Kimmel0Dawn L. Brasaemle1Monica McAndrews-Hill2Carole Sztalryd3Constantine Londos4To whom correspondence should be addressed; Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, the National Institutes of Health, Bethesda, MDDepartment of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJThe Jackson Laboratory, Bar Harbor, MEGeriatric Research Education and Clinical Center, Veterans Affairs Medical Center Department of Medicine, School of Medicine, University of Maryland, Baltimore, MDLaboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, the National Institutes of Health, Bethesda, MDThe PAT family of proteins has been identified in eukaryotic species as diverse as vertebrates, insects, and amebazoa. These proteins share a highly conserved sequence organization and avidity for the surfaces of intracellular, neutral lipid storage droplets. The current nomenclature of the various members lacks consistency and precision, deriving more from historic context than from recognition of evolutionary relationship and shared function. In consultation with the Mouse Genomic Nomenclature Committee, the Human Genome Organization Genomic Nomenclature Committee, and conferees at the 2007 FASEB Conference on Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lipids, we have established a unifying nomenclature for the gene and protein family members. Each gene member will incorporate the root term PERILIPIN (PLIN), the founding gene of the PAT family, with the different genes/proteins numbered sequentially.http://www.sciencedirect.com/science/article/pii/S0022227520305046perilipinadipocyte differentiation-related proteinadipophilintail-interacting protein of 47 kDa |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alan R. Kimmel Dawn L. Brasaemle Monica McAndrews-Hill Carole Sztalryd Constantine Londos |
spellingShingle |
Alan R. Kimmel Dawn L. Brasaemle Monica McAndrews-Hill Carole Sztalryd Constantine Londos Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins Journal of Lipid Research perilipin adipocyte differentiation-related protein adipophilin tail-interacting protein of 47 kDa |
author_facet |
Alan R. Kimmel Dawn L. Brasaemle Monica McAndrews-Hill Carole Sztalryd Constantine Londos |
author_sort |
Alan R. Kimmel |
title |
Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins |
title_short |
Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins |
title_full |
Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins |
title_fullStr |
Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins |
title_full_unstemmed |
Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins |
title_sort |
adoption of perilipin as a unifying nomenclature for the mammalian pat-family of intracellular lipid storage droplet proteins |
publisher |
Elsevier |
series |
Journal of Lipid Research |
issn |
0022-2275 |
publishDate |
2010-03-01 |
description |
The PAT family of proteins has been identified in eukaryotic species as diverse as vertebrates, insects, and amebazoa. These proteins share a highly conserved sequence organization and avidity for the surfaces of intracellular, neutral lipid storage droplets. The current nomenclature of the various members lacks consistency and precision, deriving more from historic context than from recognition of evolutionary relationship and shared function. In consultation with the Mouse Genomic Nomenclature Committee, the Human Genome Organization Genomic Nomenclature Committee, and conferees at the 2007 FASEB Conference on Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lipids, we have established a unifying nomenclature for the gene and protein family members. Each gene member will incorporate the root term PERILIPIN (PLIN), the founding gene of the PAT family, with the different genes/proteins numbered sequentially. |
topic |
perilipin adipocyte differentiation-related protein adipophilin tail-interacting protein of 47 kDa |
url |
http://www.sciencedirect.com/science/article/pii/S0022227520305046 |
work_keys_str_mv |
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