Alveolar Tissue Fiber and Surfactant Effects on Lung Mechanics—Model Development and Validation on ARDS and IPF Patients
<italic>Goal:</italic> Alveolar compliance is a main determinant of lung airflow. The compliance of the alveoli is a function of their tissue fiber elasticity, fiber volume, and surface tension. The compliance varies during respiration because of the nonlinear nature of fiber elasticity...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
IEEE
2021-01-01
|
Series: | IEEE Open Journal of Engineering in Medicine and Biology |
Subjects: | |
Online Access: | https://ieeexplore.ieee.org/document/9333664/ |
id |
doaj-c4e38d81f7834a7c893549d168e78cc0 |
---|---|
record_format |
Article |
spelling |
doaj-c4e38d81f7834a7c893549d168e78cc02021-03-29T18:58:39ZengIEEEIEEE Open Journal of Engineering in Medicine and Biology2644-12762021-01-012445410.1109/OJEMB.2021.30538419333664Alveolar Tissue Fiber and Surfactant Effects on Lung Mechanics—Model Development and Validation on ARDS and IPF PatientsJiayao Yuan0https://orcid.org/0000-0003-1004-6865Caitlyn M. Chiofolo1Benjamin J. Czerwin2https://orcid.org/0000-0003-3827-8692Nikolaos Karamolegkos3Nicolas W. Chbat4https://orcid.org/0000-0002-8802-241XColumbia University, New York, NY, USAQuadrus Medical Technologies, New York, NY, USAColumbia University, New York, NY, USAColumbia University, New York, NY, USAQuadrus Medical Technologies, New York, NY, USA<italic>Goal:</italic> Alveolar compliance is a main determinant of lung airflow. The compliance of the alveoli is a function of their tissue fiber elasticity, fiber volume, and surface tension. The compliance varies during respiration because of the nonlinear nature of fiber elasticity and the time-varying surface tension coating the alveoli. Respiratory conditions, like acute respiratory distress syndrome (ARDS) and idiopathic pulmonary fibrosis (IPF) affect fiber elasticity, fiber volume and surface tension. In this paper, we study the alveolar tissue fibers and surface tension effects on lung mechanics. <italic>Methods:</italic> To better understand the lungs, we developed a physiology-based mathematical model to 1) describe the effect of tissue fiber elasticity, fiber volume and surface tension on alveolar compliance, and 2) the effect of time-varying alveolar compliance on lung mechanics for healthy, ARDS and IPF conditions. <italic>Results:</italic> We first present the model sensitivity analysis to show the effects of model parameters on the lung mechanics variables. Then, we perform model simulation and validate on healthy non-ventilated subjects and ventilated ARDS or IPF patients. Finally, we assess the robustness and stability of this dynamic system. <italic>Conclusions:</italic> We developed a mathematical model of the lung mechanics comprising alveolar tissue and surfactant properties that generates reasonable lung pressures and volumes compared to healthy, ARDS, and IPF patient data.https://ieeexplore.ieee.org/document/9333664/Alveolar complianceARDSIPFpulmonary fiberspulmonary surfactant concentration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiayao Yuan Caitlyn M. Chiofolo Benjamin J. Czerwin Nikolaos Karamolegkos Nicolas W. Chbat |
spellingShingle |
Jiayao Yuan Caitlyn M. Chiofolo Benjamin J. Czerwin Nikolaos Karamolegkos Nicolas W. Chbat Alveolar Tissue Fiber and Surfactant Effects on Lung Mechanics—Model Development and Validation on ARDS and IPF Patients IEEE Open Journal of Engineering in Medicine and Biology Alveolar compliance ARDS IPF pulmonary fibers pulmonary surfactant concentration |
author_facet |
Jiayao Yuan Caitlyn M. Chiofolo Benjamin J. Czerwin Nikolaos Karamolegkos Nicolas W. Chbat |
author_sort |
Jiayao Yuan |
title |
Alveolar Tissue Fiber and Surfactant Effects on Lung Mechanics—Model Development and Validation on ARDS and IPF Patients |
title_short |
Alveolar Tissue Fiber and Surfactant Effects on Lung Mechanics—Model Development and Validation on ARDS and IPF Patients |
title_full |
Alveolar Tissue Fiber and Surfactant Effects on Lung Mechanics—Model Development and Validation on ARDS and IPF Patients |
title_fullStr |
Alveolar Tissue Fiber and Surfactant Effects on Lung Mechanics—Model Development and Validation on ARDS and IPF Patients |
title_full_unstemmed |
Alveolar Tissue Fiber and Surfactant Effects on Lung Mechanics—Model Development and Validation on ARDS and IPF Patients |
title_sort |
alveolar tissue fiber and surfactant effects on lung mechanics—model development and validation on ards and ipf patients |
publisher |
IEEE |
series |
IEEE Open Journal of Engineering in Medicine and Biology |
issn |
2644-1276 |
publishDate |
2021-01-01 |
description |
<italic>Goal:</italic> Alveolar compliance is a main determinant of lung airflow. The compliance of the alveoli is a function of their tissue fiber elasticity, fiber volume, and surface tension. The compliance varies during respiration because of the nonlinear nature of fiber elasticity and the time-varying surface tension coating the alveoli. Respiratory conditions, like acute respiratory distress syndrome (ARDS) and idiopathic pulmonary fibrosis (IPF) affect fiber elasticity, fiber volume and surface tension. In this paper, we study the alveolar tissue fibers and surface tension effects on lung mechanics. <italic>Methods:</italic> To better understand the lungs, we developed a physiology-based mathematical model to 1) describe the effect of tissue fiber elasticity, fiber volume and surface tension on alveolar compliance, and 2) the effect of time-varying alveolar compliance on lung mechanics for healthy, ARDS and IPF conditions. <italic>Results:</italic> We first present the model sensitivity analysis to show the effects of model parameters on the lung mechanics variables. Then, we perform model simulation and validate on healthy non-ventilated subjects and ventilated ARDS or IPF patients. Finally, we assess the robustness and stability of this dynamic system. <italic>Conclusions:</italic> We developed a mathematical model of the lung mechanics comprising alveolar tissue and surfactant properties that generates reasonable lung pressures and volumes compared to healthy, ARDS, and IPF patient data. |
topic |
Alveolar compliance ARDS IPF pulmonary fibers pulmonary surfactant concentration |
url |
https://ieeexplore.ieee.org/document/9333664/ |
work_keys_str_mv |
AT jiayaoyuan alveolartissuefiberandsurfactanteffectsonlungmechanicsx2014modeldevelopmentandvalidationonardsandipfpatients AT caitlynmchiofolo alveolartissuefiberandsurfactanteffectsonlungmechanicsx2014modeldevelopmentandvalidationonardsandipfpatients AT benjaminjczerwin alveolartissuefiberandsurfactanteffectsonlungmechanicsx2014modeldevelopmentandvalidationonardsandipfpatients AT nikolaoskaramolegkos alveolartissuefiberandsurfactanteffectsonlungmechanicsx2014modeldevelopmentandvalidationonardsandipfpatients AT nicolaswchbat alveolartissuefiberandsurfactanteffectsonlungmechanicsx2014modeldevelopmentandvalidationonardsandipfpatients |
_version_ |
1724196181749268480 |